Effect of cinnamon supplementation on blood pressure, oxidative stress, and inflammatory biomarkers in adults: An umbrella review of the meta-analyses of randomized controlled trials

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-08-24 DOI:10.1016/j.numecd.2024.08.009

Kaitian Zhang , Yang Li , Xuefeng Lin , Mazar Daneshar , Fatemeh Karamian , Mingzhu Li

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引用次数: 0

Abstract

Aims

Cinnamon has positive effects on markers of cardiometabolic health, including blood pressure (BP), oxidative stress, and inflammation. Despite the evidence accumulated from meta-analysis studies on the effects of cinnamon on these markers, the reported findings are still controversial. This umbrella review was conducted to evaluate the evidence and provide a definitive clarification.

Data synthesis

We conducted a systematic search in four scientific databases, including PubMed, Scopus, Web of Science, and Embase electronic databases, up to March 2024 to identify systematic reviews and meta-analyses of randomized clinical trials investigating the impact of cinnamon on blood pressure, oxidative stress, and inflammation. The findings revealed that cinnamon might exert favorable effects on systolic blood pressure (SBP) (ES = −2.36 mmHg; 95% CI: 3.86, −1.40), diastolic blood pressure (DBP) (ES = −1.65 mmHg; 95% CI: 2.41, −0.90), total antioxidant capacity (TAC) (WMD = 0.34; 95% CI: 0.04, 0.64), and interleukin-6 (IL-6) (WMD = −1.48; 95% CI: 2.96, −0.01). However, the results did not show any significant effect of cinnamon on malondialdehyde (MDA) (WMD = −0.47; 95% CI: 0.99, 0.05), C-reactive protein (CRP) (WMD = −1.33; 95% CI: 2.66, 0.00), and intercellular adhesion molecule 1 (ICAM-1) (WMD= 1.53, 95% CI: 12.03, 15.10).

Conclusions

The results of the studies included in this umbrella review support the usefulness of cinnamon consumption in modulating BP as well as improving TAC and IL-6 in metabolic disorders. Due to the limited number of studies, clinical diversity, and other limitations, more high-quality studies must be conducted to provide more precise and comprehensive recommendations.

Registration number

PROSPERO, CRD42023487350.

查看原文本刊更多论文

补充肉桂对成人血压、氧化应激和炎症生物标志物的影响：随机对照试验荟萃分析综述

肉桂对包括血压（BP）、氧化应激和炎症在内的心脏代谢健康指标有积极影响。尽管有关肉桂对这些指标影响的荟萃分析研究积累了大量证据，但报告的结果仍存在争议。本综述旨在对证据进行评估并提供明确的解释。我们对截至 2024 年 3 月的四个科学数据库（包括 PubMed、Scopus、Web of Science 和 Embase 电子数据库）进行了系统检索，以确定研究肉桂对血压、氧化应激和炎症影响的随机临床试验的系统综述和荟萃分析。研究结果显示，肉桂可能对收缩压（SBP）（ES = -2.36 mmHg; 95% CI: 3.86, -1.40）、舒张压（DBP）（ES = -1.65 mmHg; 95% CI: 2.41, -0.90）、总抗氧化能力（TAC）（WMD = 0.34; 95% CI: 0.04, 0.64）和白细胞介素-6（IL-6）（WMD = -1.48; 95% CI: 2.96, -0.01）。然而，结果并未显示肉桂对丙二醛（MDA）（WMD = -0.47；95% CI：0.99，0.05）、C 反应蛋白（CRP）（WMD =-1.33；95% CI：2.66，0.00）和细胞间粘附分子 1（ICAM-1）（WMD：1.53，95% CI：12.03，15.10）有任何显著影响。纳入本综述的研究结果表明，食用肉桂有助于调节血压以及改善代谢紊乱患者的 TAC 和 IL-6。由于研究数量有限、临床多样性和其他局限性，必须开展更多高质量的研究，以提供更准确、更全面的建议。prospero，CRD42023487350。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.