The serum uric acid to serum creatinine ratio is an independent risk factor for type 2 diabetes in community-dwelling elderly: A longitudinal analysis

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2024-08-30 DOI:10.1016/j.numecd.2024.08.018

Qianqian Wang , Zhaoxiang Wang , Yuyan Sun , Fengyan Tang , Bing Lu , Kaixin Zhou , Ying Pan , Shao Zhong

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引用次数: 0

Abstract

Background and aim

Elevated serum uric acid (SUA) levels are an important marker of metabolic disorders. However, SUA levels largely depend on renal clearance function. This study aims to investigate the relationship between renal function-normalized SUA [SUA to serum creatinine (SCr) ratio] and the risk of developing type 2 diabetes in a community-dwelling elderly population.

Methods and results

A retrospective cohort study was conducted on elderly, non-diabetic individuals from the Kunshan community in China, who participated in annual health check-ups between January 2018 and December 2023. The relationship between the baseline SUA/SCr ratio and the risk of type 2 diabetes was examined using Cox regression models, restricted cubic splines (RCS), and subgroup analyses. After a median follow-up of 3.88 years, 778 cases of type 2 diabetes were identified among 7671 elderly non-diabetic individuals. Adjusting for confounding variables, the baseline SUA/SCr ratio was significantly linked to type 2 diabetes risk (P < 0.001). Individuals in the highest SUA/SCr ratio quartile had a 1.323 times higher risk of developing type 2 diabetes compared to those in the lowest quartile (HR = 1.323, 95% CI 1.053–1.661, P = 0.016). RCS analysis further confirmed this positive association. Additionally, subgroup analyses suggested that this relationship was particularly pronounced in female individuals.

Conclusions

In Chinese elderly community residents, the baseline SUA/SCr ratio is linked to the risk of type 2 diabetes. Monitoring this ratio could aid in predicting and assessing the risk of type 2 diabetes.

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血清尿酸与血清肌酐的比值是社区老年人罹患 2 型糖尿病的独立风险因素：纵向分析

血清尿酸（SUA）水平升高是代谢紊乱的一个重要标志。然而，SUA 水平在很大程度上取决于肾脏清除功能。本研究旨在调查社区老年人群中肾功能正常化 SUA [SUA 与血清肌酐 (SCr) 比值] 与 2 型糖尿病发病风险之间的关系。我们对中国昆山社区的非糖尿病老年人进行了一项回顾性队列研究，这些人在2018年1月至2023年12月期间参加了年度健康体检。研究采用 Cox 回归模型、限制性立方样条（RCS）和亚组分析，考察了基线 SUA/SCr 比值与 2 型糖尿病风险之间的关系。经过中位 3.88 年的随访，在 7671 名非糖尿病老人中发现了 778 例 2 型糖尿病病例。对混杂变量进行调整后，基线 SUA/SCr 比值与 2 型糖尿病风险有显著联系（< 0.001）。与最低四分位数的人相比，SUA/SCr比率最高四分位数的人患2型糖尿病的风险高出1.323倍（HR = 1.323, 95% CI 1.053-1.661, = 0.016）。RCS 分析进一步证实了这种正相关性。此外，亚组分析表明，这种关系在女性中尤为明显。在中国老年社区居民中，基线 SUA/SCr 比值与罹患 2 型糖尿病的风险有关。监测这一比率有助于预测和评估罹患 2 型糖尿病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.