Progress in the Development of Antifouling Electrochemical Biosensors

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-03 DOI:10.2174/0115734110320891240823065902

Liuxing Chen, Da Chen, Meiling Lian

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Abstract

Electrochemical biosensors a subclass of biosensors, consisting of a biosensing element and an electrochemical transducer, have been widely used in various fields due to their excellent performance and portable device. However, in complex actual samples, non-specific adsorption of proteins and solid particles, and adhesion of cells and bacteria will lead to problems such as reduced sensor sensitivity, prolonged response time, and expanded detection errors. Therefore, constructing antifouling sensing platforms to effectively resist the bioadhesion of non-targets is crucial for the performance of biosensors. This study first introduces the commonly used classifications of electrochemical biosensors and their main contaminants. It also provides a comprehensive overview of the construction methods and application research of electrochemical antifouling sensors using different strategies, including the construction of physical, chemical and biological modification interfaces. In addition, the research progress on antifouling and antibacterial dual-action coatings for electrochemical detection is also reviewed. Finally, the challenges and future development trends of various methods are summarized, providing clues for better practical applications of electrochemical biosensors.

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防污电化学生物传感器的开发进展

电化学生物传感器是生物传感器的一个分支，由生物传感元件和电化学传感器组成，因其性能优异、装置便携而被广泛应用于各个领域。然而，在复杂的实际样品中，蛋白质和固体颗粒的非特异性吸附以及细胞和细菌的粘附会导致传感器灵敏度降低、响应时间延长和检测误差扩大等问题。因此，构建防污传感平台以有效抵御非目标物的生物粘附对生物传感器的性能至关重要。本研究首先介绍了常用的电化学生物传感器分类及其主要污染物。还全面介绍了采用不同策略的电化学防污传感器的构建方法和应用研究，包括物理、化学和生物改性界面的构建。此外，还综述了用于电化学检测的防污抗菌双效涂层的研究进展。最后，总结了各种方法面临的挑战和未来的发展趋势，为电化学生物传感器更好地实际应用提供了线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.