Investigating, Characterizing, and Optimizing Various Modified Surfaces of Titanium Dental Implants using Anodization and Physical Patterns

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-04 DOI:10.2174/0115734110313259240823103253

Hamid Reza Garshasbi, Esfandyar Askari, Ghazal Kadkhodaie Kashani, Seyed Morteza Naghib, Seyyed Mohamad Sadati Tilebon, Seyed Amirhossein Emamian, Hosseinali Ramezanpour, Hossein Eslami, Mojtaba Ansari, Malihe Salehi

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引用次数: 0

Abstract

Background: Implants made of titanium are significant in the orthopedic and dental fields. Strong osteointegration can only be achieved by surface modification technologies. The benefits of titanium are numerous, but its inert state prevents it from integrating with human cell's biologically. The titanium implant’s surface is crucial for osseointegration and implant success; hence this is necessary. How to apply osteoconductive coatings or increase the surface roughness of titanium dental implants has been investigated. Surface treatments include grit blasting, acid etching, anodizing, and coatings with calcium phosphate. Clinical efficacy has been demonstrated for most marketed surfaces (>95%). The exact involvement of surface topography and chemical reactions in early dental implant osseointegration is still unclear. Methods: Sixteen implant samples were made with different parameters. Each one has 5 parameters, including Sandblast Pressure (SP), Sandblast Cycle (SC), Anodizing Time (AT), Anodizing Voltage (AV), and Etching Time (ET). Physical and chemical characterization was used to identify optimized samples. SEM, EDS, XRD, Biodegradation, Contact Angle, Microhardness, MTT, Real-Time PCR, and Antibacterial tests were taken from the samples. Results: Different surface treatments showed that all surfaces were roughened and micro-nano structures had been shaped. The microhardness of some samples increased during surface treatment. Sample number 14 has potentially antibacterial activities. Conclusion: Future dental implants may be able to detect tissue formation and cellular attachment, which could facilitate medication release. The future of flexible, multipurpose dental implants lies in additive manufacturing, biosensing, and triggered drug-release technologies.

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利用阳极氧化和物理模式研究、表征和优化钛牙种植体的各种改性表面

背景：钛制植入物在整形外科和牙科领域具有重要意义。只有通过表面改性技术才能实现牢固的骨结合。钛的优点很多，但其惰性状态使其无法与人体细胞进行生物融合。钛种植体的表面对于骨结合和种植体的成功至关重要，因此必须进行表面处理。如何使用骨传导涂层或增加钛牙科植入物的表面粗糙度一直是研究的重点。表面处理方法包括喷砂、酸蚀、阳极氧化和磷酸钙涂层。大多数市场上销售的表面处理方法都具有临床疗效（95%）。目前还不清楚表面形貌和化学反应在早期牙科种植体骨结合中的确切作用。研究方法制作了 16 个不同参数的种植体样本。每个样品有 5 个参数，包括喷砂压力 (SP)、喷砂周期 (SC)、阳极氧化时间 (AT)、阳极氧化电压 (AV) 和蚀刻时间 (ET)。物理和化学特性分析用于确定优化样品。对样品进行了 SEM、EDS、XRD、生物降解、接触角、显微硬度、MTT、实时 PCR 和抗菌测试。结果显示不同的表面处理显示，所有样品的表面都变得粗糙，并形成了微纳米结构。一些样品的微硬度在表面处理过程中有所增加。14 号样品具有潜在的抗菌活性。结论未来的牙科植入物可能能够检测组织的形成和细胞的附着，从而促进药物的释放。灵活、多用途牙科植入体的未来在于增材制造、生物传感和触发式药物释放技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.