Exploring the Efficacy of Combining Radiofrequency Thermal Ablation or Microwave Ablation with Vertebroplasty for Pain Control and Disease Management in Metastatic Bone Disease—A Systematic Review

IF 2.8 4区医学 Q2 ONCOLOGY

Current oncology Pub Date : 2024-09-13 DOI:10.3390/curroncol31090401

Eliodoro Faiella, Federica Vaccarino, Giuseppina Pacella, Domiziana Santucci, Elva Vergantino, Amalia Bruno, Raffaele Ragone, Bruno Beomonte Zobel, Rosario Francesco Grasso

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引用次数: 0

Abstract

Background: Interventional radiology techniques have become pivotal in recent years in managing metastatic bone disease, which frequently results in skeletal complications such as fractures and severe pain. Thermoablative methods like radiofrequency ablation (RFA) and microwave ablation (MWA), when combined with vertebroplasty (VP), are proving increasingly beneficial for these patients. Methods: The search was independently conducted by two radiologists on MEDLINE databases, using specified strings up to April 2024. Methodological quality was assessed using PRISMA guidelines. Studies meeting inclusion criteria investigated thermoablation techniques (RFA and/or MWA) combined with VP, focusing on pain management and disease control outcomes in adults. Results: Among 147 results, 42 articles met the criteria, with varied prospective and retrospective designs and sample sizes averaging 49 patients, predominantly involving RFA (30 studies), MWA (11 studies), and one comparative study. Our review highlights significant pain reduction, effective local tumor control, and favorable safety of combined RFA or MWA with VP, supporting its potential in managing vertebral pathologies and warranting further clinical integration. Conclusions: The combined treatment of RFA/MWA with VP demonstrates significant pain reduction and local tumor control, with a rapid onset of analgesic effect. These findings support its crucial role in clinical practice for managing vertebral metastases.

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探讨射频热消融或微波消融与椎体成形术相结合对转移性骨病患者疼痛控制和疾病管理的疗效--系统性综述

背景：近年来，介入放射学技术已成为治疗转移性骨病的关键，转移性骨病经常导致骨折和剧烈疼痛等骨骼并发症。射频消融术（RFA）和微波消融术（MWA）等热烧蚀方法与椎体成形术（VP）相结合，对这些患者的益处越来越大。方法：由两位放射科专家在 MEDLINE 数据库中独立进行检索，使用指定字符串，检索期截至 2024 年 4 月。方法学质量按照 PRISMA 指南进行评估。符合纳入标准的研究调查了热消融技术（RFA和/或MWA）与VP的结合情况，重点关注成人的疼痛管理和疾病控制结果。结果：在 147 项研究结果中，有 42 篇文章符合标准，这些文章采用不同的前瞻性和回顾性设计，样本量平均为 49 名患者，主要涉及 RFA（30 项研究）、MWA（11 项研究）和一项对比研究。我们的综述强调了 RFA 或 MWA 与 VP 联合治疗可明显减轻疼痛、有效控制局部肿瘤并具有良好的安全性，支持其在治疗椎体病变方面的潜力，值得进一步临床整合。结论：RFA/MWA与VP的联合治疗可显著减轻疼痛和控制局部肿瘤，且镇痛效果起效迅速。这些研究结果支持其在治疗椎体转移的临床实践中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.