Isoxazolo- and 2-cyano-1-ene derivatives of dipterocarpol with antiviral activity

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4332-5

I. E. Smirnova, O. B. Kazakova

引用次数: 0

Abstract

By modifying ring A in the dammarane triterpenoid dipterocarpol, derivatives with isoxazole and 2-cyano-1-ene fragments were synthesized, which showed activity against the influenza A virus (H1N1) with selectivity indices of 19 and 23.

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具有抗病毒活性的异恶唑-和 2-氰基-1-烯双酯酚衍生物

通过修饰达玛烷三萜类化合物双酯萜酚中的 A 环，合成了具有异噁唑和 2-氰基-1-烯片段的衍生物，这些衍生物对甲型 H1N1 流感病毒具有活性，选择性指数分别为 19 和 23。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.