{"title":"Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics","authors":"Nina Sang, Yun Qi, Shun Nishimura, Eijiro Miyako","doi":"10.1002/smsc.202400324","DOIUrl":null,"url":null,"abstract":"This study presents a novel multimodal cancer theranostic platform developed using tumor cell-coated biomimetic carbon nanohorn (CNH) complexes that encapsulate the anticancer drug paclitaxel (PTX). This platform combines photothermal therapy, chemotherapy, and immunotherapy to fight against malignant colorectal cancer. These engineered nanocomplexes are designed to deliver sufficient PTX molecules into a targeted solid tumor in a light-controllable manner while inducing significant photothermal and antitumor immune responses. The outstanding photothermal conversion property of the CNHs under near-infrared light enables effective cancer cell ablation and awakening of cytotoxic immune responses. Tumor cell membrane-coated CNHs show improved water dispersibility, immune evasion, and targeting capabilities alongside enhanced immune activation against tumors. The efficacy of the biomimetic functional CNH nanocomplexes is demonstrated through excellent tumor-targeting, controlled drug-releasing behavior, and induction of cancer cell death, contributing to a robust antitumor response. This study provides a promising approach to cancer treatment by integrating multiple therapeutic modalities into a single platform, potentially enhancing treatment efficacy to combat intractable cancer.","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"232 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202400324","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This study presents a novel multimodal cancer theranostic platform developed using tumor cell-coated biomimetic carbon nanohorn (CNH) complexes that encapsulate the anticancer drug paclitaxel (PTX). This platform combines photothermal therapy, chemotherapy, and immunotherapy to fight against malignant colorectal cancer. These engineered nanocomplexes are designed to deliver sufficient PTX molecules into a targeted solid tumor in a light-controllable manner while inducing significant photothermal and antitumor immune responses. The outstanding photothermal conversion property of the CNHs under near-infrared light enables effective cancer cell ablation and awakening of cytotoxic immune responses. Tumor cell membrane-coated CNHs show improved water dispersibility, immune evasion, and targeting capabilities alongside enhanced immune activation against tumors. The efficacy of the biomimetic functional CNH nanocomplexes is demonstrated through excellent tumor-targeting, controlled drug-releasing behavior, and induction of cancer cell death, contributing to a robust antitumor response. This study provides a promising approach to cancer treatment by integrating multiple therapeutic modalities into a single platform, potentially enhancing treatment efficacy to combat intractable cancer.
期刊介绍:
Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.