Advanced strategies for 3D-printed neural scaffolds: materials, structure, and nerve remodeling

IF 8.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bio-Design and Manufacturing Pub Date : 2024-08-23 DOI:10.1007/s42242-024-00291-5

Jian He, Liang Qiao, Jiuhong Li, Junlin Lu, Zhouping Fu, Jiafang Chen, Xiangchun Zhang, Xulin Hu

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Abstract

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor functions. The potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human health. Three-dimensional (3D) printing offers versatility and precision in the fabrication of neural scaffolds. Complex neural structures such as neural tubes and scaffolds can be fabricated via 3D printing. This review comprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their design. It highlights therapeutic strategies and structural design involving neural materials and stem cells. First, nerve regeneration materials and their fabrication techniques are outlined. The applications of conductive materials in neural scaffolds are reviewed, and their potential to facilitate neural signal transmission and regeneration is highlighted. Second, the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated, and their potential to restore neural function and promote the recovery of different nervous systems is emphasized. In addition, various applications of 3D-printed neural scaffolds in peripheral and neurological diseases, as well as the design strategies of multifunctional biomimetic scaffolds, are discussed.

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三维打印神经支架的先进策略：材料、结构和神经重塑

神经再生在治疗各种骨骼和神经疾病以恢复丧失的感觉和运动功能方面具有巨大潜力。神经再生在改善神经系统疾病和损伤方面的潜力对人类健康至关重要。三维（3D）打印为神经支架的制造提供了多功能性和精确性。神经管和支架等复杂的神经结构可以通过三维打印制造。本综述全面分析了三维打印神经支架的现状，并探讨了加强其设计的策略。其中重点介绍了涉及神经材料和干细胞的治疗策略和结构设计。首先，概述了神经再生材料及其制造技术。回顾了导电材料在神经支架中的应用，并强调了其促进神经信号传输和再生的潜力。其次，全面评估了应用于周围神经和中枢神经的三维打印神经支架的进展，并强调了其恢复神经功能和促进不同神经系统恢复的潜力。此外，还讨论了三维打印神经支架在周围神经和神经系统疾病中的各种应用，以及多功能生物仿生支架的设计策略。图文摘要

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来源期刊

Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)

CiteScore

13.30

自引率

7.60%

发文量

148

期刊介绍： Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.