Serological Assessment of Lyme borreliosis in Bulgaria: A Nationwide Study

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2024-09-02 DOI:10.3390/pathogens13090754

Kim Ngoc, Iva Trifonova, Teodora Gladnishka, Evgenia Taseva, Elitsa Panayotova, Iva Vladimirova, Vladislava Ivanova, Eleonora Kuteva, Iva Christova

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Abstract

Lyme borreliosis (LB), a tick-borne infection caused by bacteria in the Borrelia burgdorferi sensu lato complex, is increasingly prevalent on the Balkan Peninsula, including Bulgaria, where it is the most common tick-borne disease. This study aimed to assess the seroprevalence of LB across Bulgaria by analyzing 1892 serum samples for specific IgG antibodies using a two-tier testing protocol involving an ELISA and immunoblot methods. The results revealed an overall seroprevalence rate of 5.4%, with significant variation based on age, sex, and residence. Seroprevalence increased with age, peaking at 8.4% in individuals over 65 years. Males had a seroprevalence of 8.4% compared to 3.3% in females, and rural residents showed higher seroprevalence (10.2%) compared to urban residents (4.4%). Regional analysis indicated that seroprevalence ranged from 0.0% to 20.0%, with higher rates in northern provinces such as Gabrovo (18.9%) and Targovishte (20.0%). This study highlights the importance of two-step testing protocols for accurate diagnosis and underscores the need for increased awareness and further research to enhance public health measures and the management of LB in Bulgaria.

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保加利亚莱姆包虫病血清学评估：一项全国性研究

莱姆包虫病（Lyme borreliosis，LB）是一种蜱虫传染病，由常染色体包柔氏包虫复合体中的细菌引起，在巴尔干半岛（包括保加利亚）日益流行，是当地最常见的蜱虫传染病。这项研究旨在通过分析 1892 份血清样本中的特异性 IgG 抗体，采用 ELISA 和免疫印迹法两级检测方案，评估保加利亚全国的结核病血清流行率。结果显示，总体血清流行率为 5.4%，不同年龄、性别和居住地的血清流行率差异显著。血清流行率随着年龄的增长而增加，65 岁以上人群的最高流行率为 8.4%。男性的血清流行率为 8.4%，而女性为 3.3%；农村居民的血清流行率（10.2%）高于城市居民（4.4%）。地区分析表明，血清流行率从 0.0% 到 20.0% 不等，加布罗沃（18.9%）和塔戈维什特（20.0%）等北部省份的血清流行率较高。这项研究强调了两步检测方案对准确诊断的重要性，并强调有必要提高认识和开展进一步研究，以加强保加利亚的公共卫生措施和枸杞多糖的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.

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