Low Rates of Immunity among Medical Students and Residents in the Era of the Resurgence of Measles

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2024-09-11 DOI:10.3390/pathogens13090784

Cristiana Ferrari, Giuseppina Somma, Vittorio Caputi, Michele Treglia, Margherita Pallocci, Fabian Cenko, Ersilia Buonomo, Mariachiara Carestia, Luca Di Giampaolo, Ole F. Olesen, Luca Coppeta

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引用次数: 0

Abstract

Measles is a highly contagious viral disease spread through respiratory droplets. The number of reported cases increased worldwide in 2023, particularly in the European Region. Italy reported 213 cases in the first quarter of 2024, with most of them in unvaccinated adults aged 15–64. Maintaining high vaccination coverage is essential to prevent outbreaks, especially in healthcare settings where measles transmission is a significant risk. In our study, we collected serological and demographic information from all Italian and foreign medical students and residents (850) who underwent a pre-training assessment at the Tor Vergata Occupational Medicine Service, Rome, between 3 April 2023 and 31 January 2024. Of the 850 students and residents analyzed, we found only 546 (64.2%) with a protective level of IgG antibodies against measles, with a median IgG level of 2.00 AI. A significant proportion of students and residents were serologically non-immune, raising concerns about the potential risk of hospital transmission. To manage this risk, it is important to assess serological levels, vaccinate those with inadequate levels, and promote vaccination in the general population.

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麻疹卷土重来之际医科学生和住院医师的免疫率较低

麻疹是一种通过呼吸道飞沫传播的高度传染性病毒性疾病。2023 年，全球报告的病例数有所增加，尤其是在欧洲地区。意大利在 2024 年第一季度报告了 213 例病例，其中大多数是 15-64 岁未接种疫苗的成年人。保持较高的疫苗接种覆盖率对于预防疫情爆发至关重要，尤其是在麻疹传播风险较大的医疗机构。在我们的研究中，我们收集了 2023 年 4 月 3 日至 2024 年 1 月 31 日期间在罗马 Tor Vergata 职业医学服务机构接受培训前评估的所有意大利和外国医科学生和住院医师（850 人）的血清学和人口统计学信息。在分析的 850 名学生和住院医师中，我们发现只有 546 人（64.2%）具有麻疹 IgG 抗体保护水平，IgG 抗体水平中位数为 2.00 AI。相当一部分学生和住院医师血清学上没有免疫力，这引起了人们对医院传播潜在风险的担忧。为了控制这一风险，必须对血清水平进行评估，为血清水平不足的人群接种疫苗，并在普通人群中推广疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.