A Novel DNA-Based Dual-Mode Data Storage System with Interrelated Concise and Detailed Data

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Ben Pei, Yongsen Zhou, Yu Yang, Jiaxiang Ma, Rangli Cao, Wen Huang, Liliang Ouyang, Shengli Mi, Zhuo Xiong
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引用次数: 0

Abstract

DNA has emerged as a promising storage medium to meet the soaring need for archival data storage because of its exceptional storage density and stability. However, current DNA-based data storage systems are incompetent of achieving high-quality random multiplexed access and frequently accessed data storage, which impedes its practical applications. Here, a dual-mode storage system is proposed that combines DNA-based archival data and nanodot-based active data. This novel data-storage system is constructed by writing the active and archival data on the same substrate through a facile two-step process involving scanning probe lithography (SPL), DNA synthesis, and chemical immobilization. The data files are categorized and stored orderly in different microregions of the substrate to achieve efficient random access. On each microregion, the nanodot array stores not only the concise information for the archival DNA data but also contains the corresponding primer sequence. Such interrelation between active and archival data allows for facilely data reading by efficient microscopic modalities and in situ polymerase chain reaction (PCR). Facilitated by the integration of nanodot and DNA, this novel dual-mode storage system demonstrates efficient data access and the potential of excellent storing capacity, paving the way for the advancement of DNA-based data storage.

Abstract Image

基于 DNA 的新型双模式数据存储系统,提供相互关联的简明和详细数据
DNA 因其出色的存储密度和稳定性,已成为一种很有前途的存储介质,可满足日益增长的档案数据存储需求。然而,目前基于 DNA 的数据存储系统无法实现高质量的随机多路访问和频繁访问数据存储,这阻碍了其实际应用。本文提出了一种双模式存储系统,将基于 DNA 的档案数据和基于纳米点的活动数据结合起来。这种新颖的数据存储系统是通过扫描探针光刻(SPL)、DNA 合成和化学固定两个简单步骤在同一基底上写入活动数据和档案数据而构建的。数据文件被分类并有序地存储在基底的不同微区,以实现高效的随机存取。在每个微区,纳米点阵列不仅存储了存档 DNA 数据的简明信息,还包含相应的引物序列。活性数据和存档数据之间的这种相互关系,可以方便地通过高效显微模式和原位聚合酶链反应(PCR)读取数据。这种新型双模式存储系统通过纳米点和 DNA 的整合,展示了高效的数据访问能力和出色的存储容量潜力,为推动基于 DNA 的数据存储铺平了道路。
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来源期刊
CiteScore
14.00
自引率
2.40%
发文量
0
期刊介绍: Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.
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