Reduction of Carboxamides Into Amines Catalyzed by La[NH-2,6-iPr2-4-FcC6H2]3/HBpin

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-09-10 DOI:10.1002/aoc.7739

Qiujin Ye, Yukun Wang, Jue Chen, Yunjie Luo

引用次数: 0

Abstract

Reduction of carboxamides is an efficient approach to obtain the corresponding amines, albeit it is one of the most problematic. In this work, by use of pinacolborane (HBpin) as a reductant, the rare-earth metal tris (arylamido) complex supported by a ferrocenyl-modified arylamido ligand La[NH-2,6-ⁱPr₂-4-FcC₆H₂]₃ was employed as a precatalyst for primary and secondary amide reductions. This catalyst system exhibited high activity toward hydroborative reduction of amides to amines under mild conditions, as well good tolerance for heteroatoms and functional groups in the reduction. A lanthanide hydride was experimentally verified as the active species and the reduction mechanism was proposed.

Abstract Image

查看原文本刊更多论文

在 La[NH-2,6-iPr2-4-FcC6H2]3/HBpin 催化下将羧酰胺还原为胺

羧酰胺的还原是获得相应胺类的有效方法，但也是最棘手的方法之一。本研究以频哪醇硼烷（HBpin）为还原剂，采用二茂铁修饰的芳酰胺配体 La[NH-2,6-iPr2-4-FcC6H2]3 支持的稀土金属三（芳酰胺）配合物作为前催化剂，进行伯胺和仲胺还原反应。这种催化剂体系在温和条件下将酰胺氢硼还原成胺的活性很高，而且对还原过程中的杂原子和官能团有很好的耐受性。实验验证了镧系氢化物是活性物种，并提出了还原机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.