Studies on Structure, Morphology and Antimicrobial and Anticancer Activities of [BMIM][BF4]-Coated ZnO Nanoparticles

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-08-18 DOI:10.1002/aoc.7700

Arumugam Rajarajeswari, Selvaraj Stella

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Abstract

Zinc oxide (ZnO) nanoparticles (NPs) coated with 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid (IL) (ZnO-[BMIM][BF₄] NPs) and ZnO NPs without IL coating were both synthesized by co-precipitation. Various analytical methods were used to characterize the synthesized NPs. X-ray diffraction (XRD) analysis revealed that ZnO NPs had a mean crystallite size of 32 nm and that of ZnO-[BMIM][BF₄] NPs was 22 nm. IL alters the Fourier transform infrared spectroscopy (FTIR) peaks of the as-prepared ZnO NPs. A blueshift was seen in the absorption peak of ZnO-[BMIM][BF₄] NPs as compared to bare ZnO NPs. An examination of the UV–visible (UV–Vis) spectra revealed that the optical bandgap decreases with the addition of IL to ZnO NPs. Scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HR-TEM) investigation revealed the morphology and size of the nanostructured particles. The chemically prepared ZnO-[BMIM][BF₄] NPs displayed the irregular spherical-shaped morphologies in the range of nanoscale. Transmission electron microscopy (TEM) showed the conventional hexagonal wurtzite structure of ZnO-[BMIM][BF₄] NPs. Synthesized ZnO-NPs in water have a zeta potential of −13.1 mV, showing that they are stable solutions. Thermal behaviour of ZnO NPs was studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The agar-well diffusion technique was used to investigate and compare the antimicrobial activity of synthesized ZnO-[BMIM][BF₄] NPs against the following bacteria and fungi: Streptococcus aureus, Pseudomonas aeruginosa and Candida albicans. The MCF7 breast cancer cells were used to assess the anticancer capabilities of ZnO-[BMIM][BF₄] NPs at various doses (100 μg/mL, 10 μg/mL, 1 μg/mL, 100 ng/mL, 10 ng/mL and 1 ng/mL) using MTT assays. The range of cell inhibition was determined to be from 19.14% to 70.52%. The percentage of cytotoxicity increases was observed when the concentration of synthesized ZnO-[BMIM][BF₄] NPs ranges from 1 ng/mL to 100 μg/mL.

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[BMIM][BF4]包覆氧化锌纳米粒子的结构、形态、抗菌和抗癌活性研究

采用共沉淀法合成了包覆 1-丁基-3-甲基咪唑四氟硼酸离子液体（IL）的氧化锌（ZnO）纳米粒子（ZnO-[BMIM][BF4] NPs）和未包覆 IL 的氧化锌（ZnO）纳米粒子（ZnO-[BMIM][BF4] NPs）。采用多种分析方法对合成的 NPs 进行了表征。X 射线衍射（XRD）分析表明，ZnO NPs 的平均晶粒尺寸为 32 nm，ZnO-[BMIM][BF4] NPs 的平均晶粒尺寸为 22 nm。IL 改变了制备的 ZnO NPs 的傅立叶变换红外光谱（FTIR）峰值。与裸 ZnO NPs 相比，ZnO-[BMIM][BF4] NPs 的吸收峰出现蓝移。对紫外-可见光谱（UV-Vis）的研究表明，ZnO NPs 中加入 IL 后，光带隙会减小。扫描电子显微镜（SEM）和高分辨率透射电子显微镜（HR-TEM）研究显示了纳米结构颗粒的形态和尺寸。化学制备的 ZnO-[BMIM][BF4]纳米粒子显示出纳米尺度范围内的不规则球形形态。透射电子显微镜（TEM）显示，ZnO-[BMIM][BF4] NPs 具有传统的六方菱面体结构。合成的 ZnO-NPs 在水中的 zeta 电位为 -13.1 mV，表明它们是稳定的溶液。使用热重分析（TGA）和差热分析（DTA）对 ZnO-NPs 的热行为进行了研究。使用琼脂-孔扩散技术研究和比较了合成的 ZnO-[BMIM][BF4] NPs 对以下细菌和真菌的抗菌活性：金黄色葡萄球菌、绿脓杆菌和白色念珠菌。利用 MTT 试验，以 MCF7 乳腺癌细胞为研究对象，评估不同剂量（100 μg/mL、10 μg/mL、1 μg/mL、100 ng/mL、10 ng/mL 和 1 ng/mL）ZnO-[BMIM][BF4] NPs 的抗癌能力。细胞抑制率范围为 19.14% 至 70.52%。当合成的 ZnO-[BMIM][BF4] NPs 的浓度从 1 ng/mL 到 100 μg/mL 时，观察到细胞毒性百分比增加。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.