Mechanisms of ferroptosis and the relationship between ferroptosis and ER stress after JEV and HSV infection

IF 4 2区生物学 Q2 MICROBIOLOGY

Frontiers in Microbiology Pub Date : 2024-09-11 DOI:10.3389/fmicb.2024.1415417

Rui Zhou, Kexin Wei, Xinyu Li, Beibei Yan, Lin Li

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Abstract

Ferroptosis is a novel form of programmed cell death, which is different from apoptosis, pyroptosis and autophagy in morphology and biochemistry. Ferroptosis is characterized by condensed mitochondrial membrane densities, vanished of mitochondria crista and outer membrane rupture in morphology, and the accumulation of intracellular iron, lipid peroxidation (LPO), decrease of GSH and inhibition of GPX4 in biochemistry. Japanese encephalitis virus (JEV) and Herpes simplex virus (HSV) are both common neurotropic viruses that can cause neurological disorders, such as severe encephalitis. JEV and HSV have been demonstrated to be able to induce ferroptosis. This process is closely related to the inhibition of the GSH-GPX4 system, ACSL4 phosphorylation, and Nrf2 ubiquitination. In this review, we summarized the mechanisms by which JEV and HSV induced ferroptosis in the current study. In addition, we found a strong relationship between endoplasmic reticulum (ER) stress and ferroptosis, and we therefore speculated that sustained ER stress might be a prerequisite for ferroptosis in JEV and HSV-induced diseases.

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JEV和HSV感染后铁蛋白沉积的机制以及铁蛋白沉积与ER应激之间的关系

铁凋亡是一种新型的程序性细胞死亡，在形态学和生物化学方面不同于细胞凋亡、热凋亡和自噬。铁凋亡的特征是线粒体膜密度浓缩、线粒体嵴消失和外膜破裂；生化特征是细胞内铁积累、脂质过氧化（LPO）、GSH 减少和 GPX4 受抑制。日本脑炎病毒（JEV）和单纯疱疹病毒（HSV）都是常见的神经性病毒，可导致神经系统疾病，如重症脑炎。事实证明，JEV 和 HSV 能够诱导铁突变。这一过程与 GSH-GPX4 系统的抑制、ACSL4 磷酸化和 Nrf2 泛素化密切相关。在这篇综述中，我们总结了目前研究中 JEV 和 HSV 诱导铁变态反应的机制。此外，我们还发现内质网（ER）应激与铁蜕变之间存在密切关系，因此我们推测持续的ER应激可能是JEV和HSV诱导的疾病中铁蜕变的先决条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Microbiology MICROBIOLOGY-

CiteScore

7.70

自引率

9.60%

发文量

4837

审稿时长

14 weeks

期刊介绍： Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.