Optical Surface Management System and BladderScan for Patient Setup During Radiotherapy of Postoperative Prostate Cancer.

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Hao Chen,Yandong Liu,Songbin Qin,Guanghui Gan
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引用次数: 0

Abstract

Background: The precision of postoperative prostate cancer radiotherapy is significantly influenced by setup errors and alterations in bladder morphology. Utilizing daily cone beam computed tomography (CBCT) imaging allows for the correction of setup errors. However, this naturally leads to the question of the issue of peripheral dose and workload. Thus, a zero-dose, noninvasive technique to reproduce the bladder volume and improve patient setup accuracy was needed. Purpose: The aim of this study is to investigate if the setup method by combining Optical Surface Management System (OSMS) and BladderScan can improve the accuracy of setup and accurately reproduce the bladder volume during radiotherapy of postoperative prostate cancer and to guide CTV-PTV margins for clinic. Method: The experimental group consisted of 15 postoperative prostate cancer patients who utilized a setup method that combined OSMS and BladderScan. This group recorded 103 setup errors, verified by CBCT. The control group comprised 25 patients, among whom 114 setup errors were recorded using the conventional setup method involving skin markers; additionally, patients in this group also exhibited spontaneous urinary suppression. The errors including lateral (Lat), longitudinal (Lng), vertical directions (Vrt), Pitch, Yaw, and Roll were analyzed between the two methods. The Dice similarity coefficient (DSC) and volume differences of the bladder between CBCT and planning CT were compared as the bladder concordance indicators. Results: The errors in the experimental group at Vrt, Lat, and Lng were 0.17 ± 0.12, 0.22 ± 0.17, and 0.18 ± 0.12 cm, and the control group were 0.25 ± 0.15, 0.31 ± 0.21, 0.34 ± 0.22 cm. The rotation errors of Pitch, Roll, and Yaw in the experimental group were 0.18 ± 0.12°, 0.11 ± 0.1°, and 0.18 ± 0.13°, and in the control group, they were 0.96 ± 0.89°, 1.01 ± 0.86°, and 1.02 ± 0.84°. The DSC and volume differences were 92.52 ± 1.65% and 39.99 ± 28.75 cm3 in the patients with BladderScan, and in the control group, they were 62.98 ± 22.33%, 273.89 ± 190.62 cm3. The P < 0.01 of the above performance indicators indicates that the difference is statistically significant. Conclusion: The accuracy of the setup method by combining OSMS and BladderScan was validated by CBCT in our study. The method in our study can improve the setup accuracy during radiotherapy of postoperative prostate cancer compared to the conventional setup method.
用于前列腺癌术后放疗期间患者设置的光学表面管理系统和膀胱扫描系统
背景:前列腺癌术后放疗的精确性受到设置误差和膀胱形态改变的严重影响。利用日常锥形束计算机断层扫描(CBCT)成像可以纠正设置误差。然而,这自然会引出外围剂量和工作量的问题。因此,需要一种零剂量、无创的技术来重现膀胱容积并提高患者设置的准确性。目的:本研究旨在探讨光学表面管理系统(OSMS)和膀胱扫描相结合的设置方法是否能提高设置的准确性,并在前列腺癌术后放疗过程中准确再现膀胱容积,指导临床的 CTV-PTV 边缘。实验方法实验组由 15 名前列腺癌术后患者组成,他们使用了结合 OSMS 和 BladderScan 的设置方法。经 CBCT 验证,该组记录了 103 次设置错误。对照组由 25 名患者组成,其中 114 名患者使用传统的皮肤标记设置方法记录了设置错误;此外,该组患者还表现出自发性尿抑制。分析了两种方法的误差,包括横向(Lat)、纵向(Lng)、垂直方向(Vrt)、俯仰(Pitch)、偏航(Yaw)和滚动(Roll)。作为膀胱一致性指标,比较了 CBCT 与规划 CT 的 Dice 相似系数(DSC)和膀胱容积差异。结果实验组的 Vrt、Lat 和 Lng 误差分别为 0.17 ± 0.12、0.22 ± 0.17 和 0.18 ± 0.12 cm,对照组分别为 0.25 ± 0.15、0.31 ± 0.21 和 0.34 ± 0.22 cm。实验组的俯仰、翻滚和偏航旋转误差分别为 0.18 ± 0.12°、0.11 ± 0.1°和 0.18 ± 0.13°,对照组分别为 0.96 ± 0.89°、1.01 ± 0.86°和 1.02 ± 0.84°。BladderScan患者的DSC和体积差异分别为(92.52±1.65)%和(39.99±28.75)cm3,对照组分别为(62.98±22.33)%和(273.89±190.62)cm3。上述性能指标的 P < 0.01 表明差异具有统计学意义。结论我们的研究通过 CBCT 验证了结合 OSMS 和 BladderScan 的设置方法的准确性。与传统的设置方法相比,我们研究中的方法可以提高前列腺癌术后放疗的设置准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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