Systemic chemotherapy in addition to CRS‐HIPEC for colorectal peritoneal metastases: A critical systematic review on the impact on overall survival

IF 2 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI:10.1002/jso.27849

Teun B. M. van den Heuvel, Robin J. Lurvink, Koen P. B. Rovers, Irene E. G. van Hellemond, Ignace H. J. T. de Hingh

引用次数: 0

Abstract

In patients with resectable colorectal peritoneal metastases, it is unclear whether systemic chemotherapy, in addition to cytoreductive surgery‐hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC), improves overall survival (OS). This systematic review of 12 retrospective studies involving 3721 patients aimed to summarize the available evidence. Contradictory results were found regarding the effectiveness of neoadjuvant, adjuvant, and perioperative systemic therapies on OS, with a high risk of bias. Available evidence remains inconclusive, stressing the need for prospective, randomized trials, like the ongoing Dutch CAIRO6‐trial.

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治疗结直肠腹膜转移瘤的CRS-HIPEC基础上的全身化疗：对总生存期影响的关键性系统综述

对于可切除的结直肠腹膜转移瘤患者，目前尚不清楚在进行囊肿切除手术-腹腔内热化疗（CRS-HIPEC）的同时进行全身化疗是否能提高总生存率（OS）。本系统性综述对涉及3721名患者的12项回顾性研究进行了分析，旨在总结现有证据。在新辅助治疗、辅助治疗和围手术期系统治疗对 OS 的有效性方面发现了相互矛盾的结果，偏倚风险较高。现有证据仍无定论，强调需要进行前瞻性随机试验，如正在进行的荷兰 CAIRO6 试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.