Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities

IF 2.9 4区 医学 Q3 CHEMISTRY, MEDICINAL
Kulbhushan Thakur, Tejveer Singh, Deepika Sharma, Nipun Padha, Bilal Ahmad Mir, Atika Chandra, Vijay Rani Rajpal
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Abstract

: Traditional medicinal foods derived from natural sources have gained increasing attention in recent years due to their perceived health benefits and potential therapeutic properties and are deeply rooted in cultural practices. This review aimed at understanding their potential health benefits, emphasizes the need to identify the key bioactive substances in traditional home medicine. We have discussed the bioactive properties, molecular targets, and anti-cancer effects of various compounds such as curcumin, genistein, berberine, resveratrol, and, quercetin present in traditional medicinal foods. Our study highlights the potential of traditional medicinal food in the prevention and management of various health conditions, including cardiovascular diseases, cancer and neurodegenerative disorders as evident from in vitro, in vivo and clinical trials. Additionally, our study explores the mechanistic action of various bioactive constituents of grapes, rosemary, barberry, turmeric and garlic that have been shown to interfere with cancer growth, proliferation, metastasis, angiogenesis, and induce apoptosis by targeting various pathways and the cell cycle. Additionally, a wide range of healing abilities of medicinal foods including their impact on cancer cells demonstrate their direct anti-tumor potential along with antioxidant and antiinflammatory properties. To summarize, the present review highlights that integrating the insights of contemporary science with the age-old wisdom of traditional medicine in a systematic way holds immense potential for developing alternate and effective approaches to cancer therapeutics and offering evidence-based dietary recommendations.
探索传统药用食品在癌症治疗中的治疗潜力:分子证据和生物活性
:近年来,从天然资源中提取的传统药用食品越来越受到人们的关注,因为它们具有明显的健康益处和潜在的治疗特性,并深深植根于文化习俗之中。本综述旨在了解其潜在的健康益处,强调有必要确定传统家庭药膳中的关键生物活性物质。我们讨论了传统药膳中姜黄素、染料木素、小檗碱、白藜芦醇和槲皮素等多种化合物的生物活性特性、分子靶点和抗癌作用。我们的研究强调了传统药用食品在预防和治疗心血管疾病、癌症和神经退行性疾病等各种健康状况方面的潜力,这一点在体外、体内和临床试验中都得到了证实。此外,我们的研究还探讨了葡萄、迷迭香、巴比妥、姜黄和大蒜中各种生物活性成分的作用机理,这些成分已被证明可以通过靶向各种途径和细胞周期,干扰癌症的生长、增殖、转移、血管生成并诱导细胞凋亡。此外,药用食品具有广泛的治疗能力,包括对癌细胞的影响,这表明它们具有直接抗肿瘤的潜力以及抗氧化和抗炎特性。总之,本综述强调,以系统的方式将当代科学的见解与传统医学的古老智慧相结合,在开发替代性有效癌症治疗方法和提供循证膳食建议方面具有巨大潜力。
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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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