Comparison of Prognostic Performance of 8th and 7th Edition of AJCC Staging System for Patients With Gallbladder Cancer Undergoing Curative Intent Surgery

IF 2 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2024-09-11 DOI:10.1002/jso.27875

Sameer Gupta, Abhishek Verma, Arun Chaturvedi, Puneet Prakash, Vijay Kumar, Sanjeev Misra, Naseem Akhtar, Shiv Rajan, Preeti Agarwal, Lynette Smith, Makayla Schissel, Chandrakanth Are

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Abstract

BackgroundWe compared the predictive performance of the 7th and 8th editions of the AJCC staging systems in stratifying disease‐related survival outcomes in patients with GBC undergoing curative intent surgery.MethodsPatients that underwent curative intent surgery for GBC at our institution (2014 and 2021) were included in the study. Various clinico‐pathological data were extracted to perform Kaplan–Meier survival analysis.ResultsA total of 240 patients were included in the study. Both, TNM‐7, and TNM‐8 staging systems can stratify patients into stages with statistically significant differences in disease‐free and overall survival. Survival rates drop with stage progression. Using TNM‐8, 8/240 (3.33%) patients were upstaged from Stage IIIB (TNM‐7) to IVB (TNM‐8) and 12/240 (5%) were down‐staged from Stage IVB(TNM‐7) to IIIB(TNM‐8). Survival curves of the re‐classified patients matched those of the corresponding TNM‐8 stage. Additionally, there was statistically significant difference in their survival (p < 0.001) compared to their corresponding TNM‐7 stage. There was no statistically significant difference in survival rates between stages IIA, IIB (TNM‐8), and stage II (TNM‐7). However, stage IIA had a slightly better survival than stage IIB.ConclusionThough both TNM‐7 and TNM‐8 are useful for stratifying patients with GBC, TNM‐8 has a better prognostic performance than TNM‐7.

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比较 AJCC 第 8 版和第 7 版分期系统对接受治愈性手术的胆囊癌患者的预后效果

背景我们比较了第7版和第8版AJCC分期系统在对接受根治性手术的GBC患者进行疾病相关生存结局分层时的预测性。结果共纳入 240 例患者。TNM-7和TNM-8分期系统都能对患者进行分期，无病生存率和总生存率在统计学上有显著差异。生存率随着分期的进展而下降。使用TNM-8，8/240（3.33%）名患者从IIIB期（TNM-7）升至IVB期（TNM-8），12/240（5%）名患者从IVB期（TNM-7）降至IIIB期（TNM-8）。重新分期患者的生存曲线与相应TNM-8分期患者的生存曲线一致。此外，与相应的 TNM-7 期相比，他们的生存率有显著的统计学差异（p < 0.001）。IIA期、IIB期（TNM-8）和II期（TNM-7）之间的生存率差异无统计学意义。结论尽管TNM-7和TNM-8都可用于对GBC患者进行分层，但TNM-8的预后效果优于TNM-7。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.