Complexes R2Sn(IV)L with Tridentate O,N,O'-Donor Schiff Bases: Photophysical Properties and Biological Activity

IF 1.1 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Coordination Chemistry Pub Date : 2024-08-21 DOI:10.1134/s1070328424600293

D. A. Burmistrova, N. P. Pomortseva, K. D. Pashaeva, M. P. Polovinkina, N. R. Al’myasheva, F. M. Dolgushin, E. D. Tselukovskaya, I. V. Anan’ev, O. P. Demidov, A. I. Poddel’skii, N. T. Berberova, I. L. Eremenko, I. V. Smolyaninov

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引用次数: 0

Abstract

New tin(IV) complexes (Lⁿ)SnR₂ (R = n-Bu (I, II), t-Bu (III–V), and Ph (VI)) with O,N,O'-donor Schiff bases are synthesized. The molecular structures of compounds I and IV in the crystalline state are determined by XRD (CIF files CCDC nos. 2309864 (I) and 2309422 (IV)). The photophysical properties of the complexes are studied in comparison with the previously synthesized compounds containing phenyl or ethyl hydrocarbon groups at the tin atom. All compounds luminesce in chloroform: the emission bands are observed in the range from 580 to 638 nm. Both the groups at the tin atom and nature of the substituents in Schiff bases significantly affect the relative quantum yield. The anti/prooxidant activity of (Lⁿ)SnR₂ in the reactions with the ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)) radical cation and superoxide radical anion, in the oxidative DNA damage, and during lipid peroxidation in vitro is studied. A weak antibacterial activity against the bacterial strains Staphylococcus aureus ANCC 6538 and E. faecium ATCC 3576 are observed for some compounds. The in vitro antiproliferative properties for a number of the complexes are studied for the HTC-116 and А-549 cancer cell lines. The coordination of the organometallic fragment with the O,N,O'-tridentate ligands is found to induce a pronounced decrease in the cytotoxicity of the complexes.

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R2Sn(IV)L 与三叉 O,N,O'-单体席夫碱的配合物：光物理性质和生物活性

摘要合成了新的锡(IV)配合物 (Ln)SnR2（R = n-Bu（I，II），t-Bu（III-V）和 Ph（VI））与 O，N，O'-主席夫碱。通过 X 射线衍射（CIF 文件 CCDC 编号：2309864 (I) 和 2309422 (IV)）确定了晶体态化合物 I 和 IV 的分子结构。通过与之前合成的在锡原子上含有苯基或乙基烃基的化合物进行比较，研究了这些复合物的光物理特性。所有化合物都在氯仿中发光：在 580 至 638 纳米范围内观察到发射带。锡原子上的基团和希夫碱中取代基的性质都会对相对量子产率产生重大影响。研究了 (Ln)SnR2 在与 ABTS（2,2'-偶氮双（3-乙基苯并噻唑啉-6-磺酸））自由基阳离子和超氧自由基阴离子反应、DNA 氧化损伤以及体外脂质过氧化过程中的抗氧化活性。观察到一些化合物对细菌菌株金黄色葡萄球菌 ANCC 6538 和粪大肠杆菌 ATCC 3576 有微弱的抗菌活性。研究了一些复合物对 HTC-116 和 А-549 癌细胞株的体外抗增殖特性。研究发现，有机金属片段与 O,N,O'-三叉配体的配位会明显降低配合物的细胞毒性。

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来源期刊

Russian Journal of Coordination Chemistry 化学-无机化学与核化学

CiteScore

2.40

自引率

15.80%

发文量

审稿时长

7.2 months

期刊介绍： Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.