Piezo‐biphasic scaffold based on polycaprolactone containing BaTiO3 and hydroxyapatite nanoparticles using three‐dimensional printing for bone regeneration

IF 1.8 4区 材料科学 Q2 MATERIALS SCIENCE, CERAMICS
Roza Salehi Sadati, Hossein Eslami, Mohammad Rafienia, Mojtaba Ansari
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引用次数: 0

Abstract

The present study intends to establish biphasic composite scaffolds containing polycaprolactone/hydroxyapatite (PCL/HA) and PCL/barium titanate (PCL/BT) layers with improved mechanical and biological properties by preserving HA and tuning BT contents. The porous piezo‐biphasic scaffolds were fabricated, using extrusion three‐dimensional printer technology, and on the basis of the scanning electron microscopy results, a relative porosity of 210–250 µm was created. The presence of BT phase in the biphasic scaffolds was confirmed by X‐ray diffraction and Fourier transform infrared analyses. The printed biphasic composites demonstrate suitable mechanical strength compared to one containing only 35% PCL and 65% HA compositions, which had a strength of 2.5 MPa. However, the strength for 80% BT‐incorporated biphasic composite was almost 13.5 times higher than that of monolithic specimen. The measured output voltages for the scaffolds after being subjected to an electric field affirmed that adding BT nanoparticles in biphasic composites leads to an increase in the output voltage that was lower compared to the monolithic scaffold. The piezo‐biphasic scaffold containing 80% BT is found to possess the highest enhancement in cytocompatibility for MG63 cells with the survival rate of approximately 95%, rendering the PCL/HA–PCL/BT biphasic scaffolds promising candidates for bone regeneration.
基于含有 BaTiO3 和羟基磷灰石纳米颗粒的聚己内酯的压电双相支架,利用三维打印技术实现骨再生
本研究旨在通过保留 HA 和调整 BT 的含量,建立含有聚己内酯/羟基磷灰石(PCL/HA)层和 PCL/钛酸钡(PCL/BT)层的双相复合支架,以改善其机械和生物特性。利用挤压式三维打印机技术制作了多孔压电双相支架,根据扫描电子显微镜结果,其相对孔隙率为 210-250 µm。X 射线衍射和傅立叶变换红外分析证实了双相支架中 BT 相的存在。与仅含 35% PCL 和 65% HA 成分的双相复合材料相比,打印出的双相复合材料具有合适的机械强度,后者的强度为 2.5 兆帕。然而,80% BT 加入的双相复合材料的强度几乎是单片试样的 13.5 倍。支架在电场作用下的输出电压测量结果表明,在双相复合材料中添加 BT 纳米粒子可提高输出电压,但输出电压低于单片支架。研究发现,含有 80% BT 的压电双相支架对 MG63 细胞的细胞相容性有最高的增强效果,存活率约为 95%,因此 PCL/HA-PCL/BT 双相支架有望用于骨再生。
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来源期刊
International Journal of Applied Ceramic Technology
International Journal of Applied Ceramic Technology 工程技术-材料科学:硅酸盐
CiteScore
3.90
自引率
9.50%
发文量
280
审稿时长
4.5 months
期刊介绍: The International Journal of Applied Ceramic Technology publishes cutting edge applied research and development work focused on commercialization of engineered ceramics, products and processes. The publication also explores the barriers to commercialization, design and testing, environmental health issues, international standardization activities, databases, and cost models. Designed to get high quality information to end-users quickly, the peer process is led by an editorial board of experts from industry, government, and universities. Each issue focuses on a high-interest, high-impact topic plus includes a range of papers detailing applications of ceramics. Papers on all aspects of applied ceramics are welcome including those in the following areas: Nanotechnology applications; Ceramic Armor; Ceramic and Technology for Energy Applications (e.g., Fuel Cells, Batteries, Solar, Thermoelectric, and HT Superconductors); Ceramic Matrix Composites; Functional Materials; Thermal and Environmental Barrier Coatings; Bioceramic Applications; Green Manufacturing; Ceramic Processing; Glass Technology; Fiber optics; Ceramics in Environmental Applications; Ceramics in Electronic, Photonic and Magnetic Applications;
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