Chronic exposure to MK-801 leads to olfactory deficits and reduced neurogenesis in the olfactory bulbs of adult male mice

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Artem Sinegubov, Vyacheslav Dyachuk
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Abstract

BackgroundMK-801 is a drug widely used in preclinical studies to model schizophrenia in animals. Its distinctive feature is the ability to mimic pathological changes in social interactions. Unlike humans, rodents rely heavily on their sense of smell for social interaction. Since, as previously demonstrated, it also impairs neurogenesis, we set out to determine whether olfactory impairment is associated with chronic administration of the drug.MethodsThe mice were divided into two groups, of which one was administered the drug for 3 weeks, and the other only once. Olfaction and social transfer of food preferences were tested after the drug administration period. At the end of the experiment, an immunofluorescence study was performed to determine differences in neurogenesis in the olfactory bulbs.ResultsAn olfactory deficit was observed in animals that received the drug for 3 weeks. These changes were also accompanied by an abnormal lack of food preference in the social transmission test. As a result of a morphological study, a pronounced decrease in the number of new neurons was found in the olfactory bulbs of the animals that had received the drug.ConclusionOur results indicate that at least some of the impairments in social behavior of the animals exposed to NMDA receptor antagonists are likely caused by changes in the sense of smell. These changes are associated with disruptions of neurogenesis.
长期暴露于 MK-801 会导致成年雄性小鼠嗅球的嗅觉缺陷和神经发生减少
背景MK-801是一种在临床前研究中广泛用于动物精神分裂症模型的药物。它的显著特点是能够模拟社会交往中的病理变化。与人类不同,啮齿类动物主要依靠嗅觉进行社会交往。我们将小鼠分为两组,一组连续服药 3 周,另一组只服药一次。给药后测试嗅觉和食物偏好的社会转移。实验结束后,进行了免疫荧光研究,以确定嗅球神经发生的差异。这些变化还伴随着在社会传递测试中对食物缺乏偏好的异常现象。结论我们的研究结果表明,至少有一部分暴露于 NMDA 受体拮抗剂的动物的社会行为障碍可能是由嗅觉变化引起的。这些变化与神经发生紊乱有关。
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来源期刊
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
4.70
自引率
3.30%
发文量
506
审稿时长
6-12 weeks
期刊介绍: Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.
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