Role of Deoxyribonucleic Acid Origami for Alleviating Kidney and Liver Injury in Diabetic Sepsis

IF 3.8 2区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of Proteome Research Pub Date : 2024-09-12 DOI:10.1021/acs.jproteome.4c00543

Xinmei Luo, Wenshu Dai, Tianhai Lin, Ling Li, Yong Zhang

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Abstract

Treating diabetic sepsis (DS) can be challenging because of the persistent infection of multiple organs. To address this complicated pathological condition, it is necessary to develop advanced materials and gain a better understanding of their roles. In this study, we developed a two-dimensional planar material with a rectangular deoxyribonucleic acid origami nanostructure (termed Rec-DON). Rec-DON was used to improve liver and renal function in DS mice, as it preferentially accumulates in these organs, and has superior anti-inflammatory activity and the ability to scavenge reactive oxygen species. The role of Rec-DON in the treatment of DS mice was investigated via quantitative proteomics. This study revealed that Rec-DON can regulate key proteins located primarily in the cytoplasm and mitochondrion, involved in protein transport, antigen processing and presentation, and steroid metabolic process, and can also bind to various proteins to restore liver and renal function in DS mice. This study presented Rec-DON as a liver and kidney targeting material and revealed its role in alleviating multiorgan injury in DS.

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脱氧核糖核酸折纸在缓解糖尿病败血症肝肾损伤中的作用

由于糖尿病败血症（DS）会造成多个器官的持续感染，因此治疗难度很大。为了解决这一复杂的病理条件，有必要开发先进的材料，并更好地了解它们的作用。在这项研究中，我们开发了一种具有矩形脱氧核糖核酸折纸纳米结构的二维平面材料（称为 Rec-DON）。Rec-DON 可用于改善 DS 小鼠的肝脏和肾脏功能，因为它优先在这些器官中积聚，并具有卓越的抗炎活性和清除活性氧的能力。研究人员通过定量蛋白质组学研究了 Rec-DON 在治疗 DS 小鼠中的作用。这项研究发现，Rec-DON 能调节主要位于细胞质和线粒体的关键蛋白，这些蛋白参与蛋白质转运、抗原处理和呈递以及类固醇代谢过程，还能与多种蛋白结合，从而恢复 DS 小鼠的肝脏和肾脏功能。这项研究介绍了 Rec-DON 作为肝脏和肾脏靶向材料的作用，并揭示了它在缓解 DS 多器官损伤方面的作用。

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来源期刊

Journal of Proteome Research 生物-生化研究方法

CiteScore

9.00

自引率

4.50%

发文量

251

审稿时长

3 months

期刊介绍： Journal of Proteome Research publishes content encompassing all aspects of global protein analysis and function, including the dynamic aspects of genomics, spatio-temporal proteomics, metabonomics and metabolomics, clinical and agricultural proteomics, as well as advances in methodology including bioinformatics. The theme and emphasis is on a multidisciplinary approach to the life sciences through the synergy between the different types of "omics".