Toxicologic Pathology Forum*: mRNA Vaccine Safety–Separating Fact From Fiction

IF 1.4 4区 医学 Q3 PATHOLOGY
Rani S. Sellers, Philip R. Dormitzer
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引用次数: 0

Abstract

SARS-CoV-2 spread rapidly across the globe, contributing to the death of millions of individuals from 2019 to 2023, and has continued to be a major cause of morbidity and mortality after the pandemic. At the start of the pandemic, no vaccines or anti-viral treatments were available to reduce the burden of disease associated with this virus, as it was a novel SARS coronavirus. Because of the tremendous need, the development of vaccines to protect against COVID-19 was critically important. The flexibility and ease of manufacture of nucleic acid–based vaccines, specifically mRNA-based products, allowed the accelerated development of COVID-19 vaccines. Although mRNA-based vaccines and therapeutics had been in clinical trials for over a decade, there were no licensed mRNA vaccines on the market at the start of the pandemic. The rapid development of mRNA-based COVID-19 vaccines reduced serious complications and death from the virus but also engendered significant public concerns, which continue now, years after emergency-use authorization and subsequent licensure of these vaccines. This article summarizes and addresses some of the safety concerns that continue to be expressed about these vaccines and their underlying technology.
毒理病理学论坛*:mRNA 疫苗安全性--分清事实与虚构
从 2019 年到 2023 年,SARS-CoV-2 在全球迅速蔓延,导致数百万人死亡,在大流行之后,它仍然是发病和死亡的主要原因。大流行之初,由于该病毒是一种新型 SARS 冠状病毒,因此没有疫苗或抗病毒治疗方法来减轻与之相关的疾病负担。由于需求量巨大,开发可预防 COVID-19 的疫苗就显得至关重要。以核酸为基础的疫苗,特别是以 mRNA 为基础的产品的灵活性和易制造性使 COVID-19 疫苗的开发得以加速。尽管基于 mRNA 的疫苗和疗法已进行了十多年的临床试验,但在大流行开始时,市场上还没有获得许可的 mRNA 疫苗。基于 mRNA 的 COVID-19 疫苗的快速开发减少了病毒造成的严重并发症和死亡,但也引起了公众的极大关注,这种关注在这些疫苗获得紧急使用授权和随后的许可多年后的今天仍在继续。本文总结并讨论了人们对这些疫苗及其基础技术的安全性持续表达的一些担忧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Toxicologic Pathology
Toxicologic Pathology 医学-病理学
CiteScore
4.70
自引率
20.00%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.
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