Fabrication and Characterization of Carrageenan‐Biopolymer Composite Microneedles for Interstitial Fluid Collection

IF 2.5 4区 化学 Q3 POLYMER SCIENCE
Shreya Shashank Chauhan, Venkata Vamsi Krishna Venuganti
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Abstract

Identification of suitable polymeric materials to fabricate microneedles (MNs) for the collection of interstitial fluid (ISF) is a challenge. Here, characterization of different carrageenan‐biopolymer composites for MN patch fabrication intended for ISF collection is reported. Systematic oscillatory rheological studies of composites containing iota‐carrageenan mixed with alginate, gelatin, or pectin are performed to determine the linear viscoelastic region, gel point, tan delta, complex viscosity, and flow transition index. A polynomial equation is derived by relating flow transition index of biopolymer composites and compression strength of fabricated MNs. The biopolymer composite of iota‐carrageenan and gelatin at 2% and 14%, respectively, and CaCl2 crosslinker (80 mm) shows the greatest compression strength sufficient for MNs insertion into the excised porcine skin. MNs swell up on application in an agarose gel model and the ex vivo excised porcine skin model to collect 36 ± 5 and 14 ± 1 µL of fluid within 10 min, respectively. Taken together, it is demonstrated that rheological analysis can be performed to select suitable polymer composites that possess sufficient strength for the skin insertion and swellability for ISF collection.
用于间质液体收集的卡拉胶-生物聚合物复合微针的制作与特性分析
寻找合适的聚合物材料来制造微针(MN)以收集组织间液(ISF)是一项挑战。本文报告了不同卡拉胶-生物聚合物复合材料的特性,这些复合材料可用于制造用于收集间质液的微针。对含有混有海藻酸、明胶或果胶的异卡拉胶的复合材料进行了系统的振荡流变学研究,以确定线性粘弹性区域、凝胶点、tan delta、复合粘度和流动转变指数。通过将生物聚合物复合材料的流动转变指数与制成的 MN 的压缩强度联系起来,得出了一个多项式方程。由分别为 2% 和 14% 的 iota-carrageenan 和明胶以及 CaCl2 交联剂(80 毫米)组成的生物聚合物复合材料显示出最大的压缩强度,足以将 MNs 插入切除的猪皮肤中。MNs 在琼脂糖凝胶模型和体外切除猪皮肤模型中应用时会膨胀,在 10 分钟内分别收集到 36 ± 5 µL 和 14 ± 1 µL 的液体。综上所述,可以通过流变分析来选择合适的聚合物复合材料,这些复合材料既要有足够的强度用于皮肤插入,又要有足够的膨胀性用于收集 ISF。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Macromolecular Chemistry and Physics
Macromolecular Chemistry and Physics 化学-高分子科学
CiteScore
4.30
自引率
4.00%
发文量
278
审稿时长
1.4 months
期刊介绍: Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.
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