{"title":"Fabrication and Characterization of Carrageenan‐Biopolymer Composite Microneedles for Interstitial Fluid Collection","authors":"Shreya Shashank Chauhan, Venkata Vamsi Krishna Venuganti","doi":"10.1002/macp.202400160","DOIUrl":null,"url":null,"abstract":"Identification of suitable polymeric materials to fabricate microneedles (MNs) for the collection of interstitial fluid (ISF) is a challenge. Here, characterization of different carrageenan‐biopolymer composites for MN patch fabrication intended for ISF collection is reported. Systematic oscillatory rheological studies of composites containing iota‐carrageenan mixed with alginate, gelatin, or pectin are performed to determine the linear viscoelastic region, gel point, tan delta, complex viscosity, and flow transition index. A polynomial equation is derived by relating flow transition index of biopolymer composites and compression strength of fabricated MNs. The biopolymer composite of iota‐carrageenan and gelatin at 2% and 14%, respectively, and CaCl<jats:sub>2</jats:sub> crosslinker (80 m<jats:sc>m</jats:sc>) shows the greatest compression strength sufficient for MNs insertion into the excised porcine skin. MNs swell up on application in an agarose gel model and the ex vivo excised porcine skin model to collect 36 ± 5 and 14 ± 1 µL of fluid within 10 min, respectively. Taken together, it is demonstrated that rheological analysis can be performed to select suitable polymer composites that possess sufficient strength for the skin insertion and swellability for ISF collection.","PeriodicalId":18054,"journal":{"name":"Macromolecular Chemistry and Physics","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Chemistry and Physics","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/macp.202400160","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Identification of suitable polymeric materials to fabricate microneedles (MNs) for the collection of interstitial fluid (ISF) is a challenge. Here, characterization of different carrageenan‐biopolymer composites for MN patch fabrication intended for ISF collection is reported. Systematic oscillatory rheological studies of composites containing iota‐carrageenan mixed with alginate, gelatin, or pectin are performed to determine the linear viscoelastic region, gel point, tan delta, complex viscosity, and flow transition index. A polynomial equation is derived by relating flow transition index of biopolymer composites and compression strength of fabricated MNs. The biopolymer composite of iota‐carrageenan and gelatin at 2% and 14%, respectively, and CaCl2 crosslinker (80 mm) shows the greatest compression strength sufficient for MNs insertion into the excised porcine skin. MNs swell up on application in an agarose gel model and the ex vivo excised porcine skin model to collect 36 ± 5 and 14 ± 1 µL of fluid within 10 min, respectively. Taken together, it is demonstrated that rheological analysis can be performed to select suitable polymer composites that possess sufficient strength for the skin insertion and swellability for ISF collection.
期刊介绍:
Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.