Efficient synthesis of acetylsalicylic acid over Y-immobilized cation exchange resin conjoined ultrasonic collaborative method under mild conditions

IF 2.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2024-09-03 DOI:10.1007/s11164-024-05381-8

Jiaqi Yan, Gui Chen, Jixia Li, Sitong Wang, Yang Tan, Ye Yuan

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Abstract

A mild strategy was developed for efficient preparation of acetylsalicylic acid (ASA) from the acetylation of salicylic acid (SA) and acetic anhydride (AA) assisted ultrasonic over Y-immobilized cation exchange resin (Y-CER). With this strategy, an ASA yield of 95.2% was obtained. The results showed that the increased yield was due to Lewis acidic sites (LAS) combined with ultrasonic assistance. The process reduced the AA reagent feed while lowering the reaction temperature. The characterization results showed that metal Y species were dispersedly anchored on the CER surface through S-O-Y triple-dentate bonds, resulting in abundant LAS and stable catalytic activity. Comparative experiments revealed that LAS was more favorable for the formation of ASA than Bronsted acidic sites (BAS). Furthermore, a plausible mechanism for the acetylation of SA and AA by Y-CER has been proposed. This work provided a practical protocol for improving ASA yield and reducing acid wastewater discharge, with potential application prospects.

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在温和条件下通过 Y-immobilized 阳离子交换树脂结合超声波协同法高效合成乙酰水杨酸

在 Y-imobilized 阳离子交换树脂（Y-CER）的超声波辅助下，开发了一种温和的策略，用于从水杨酸（SA）和乙酸酐（AA）的乙酰化反应中高效制备乙酰水杨酸（ASA）。通过这种策略，ASA 的收率达到 95.2%。结果表明，产率的提高得益于路易斯酸性位点（LAS）与超声波辅助的结合。该工艺在降低反应温度的同时减少了 AA 试剂的进料量。表征结果表明，金属 Y 物种通过 S-O-Y 三齿键分散锚定在 CER 表面，从而产生了丰富的路易斯酸位点和稳定的催化活性。对比实验表明，LAS 比布朗斯特酸性位点（BAS）更有利于 ASA 的形成。此外，还提出了 Y-CER 对 SA 和 AA 进行乙酰化的合理机制。这项工作为提高 ASA 产量和减少酸性废水排放提供了一个实用方案，具有潜在的应用前景。

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.