ESIPT performance bis-Schiff base for multifunctional detection of Pb2+, Mg2+ and Al3+ ions through “turn-on” response and its biological application

IF 2.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2024-09-02 DOI:10.1007/s11164-024-05386-3

Lu Li, Jianing Zhao, Chengwei Lü

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Abstract

Benzothiazole, hydrazine/ammonia and salicylaldehyde were selected as basic unit for constructing of bis-Schiff base molecules with excited state intramolecular proton transfer (ESIPT) property. Herein, “turn-on” fluorescent performance and highly sensitive multifunctional fluorescence probes were developed to stably and efficiently detect Pb²⁺, Mg²⁺ and Al³⁺ in biological and environmental samples. Among them, BF-SJ could distinguish Pb²⁺ and Mg²⁺ ions under different pH conditions, while BF-SO could separate Pb²⁺ and Al³⁺ by different emission wavelength. More important, target ions could be distinguished by naked eyes with color change of solution under sun light and ultraviolet lamp. The LOD values of BF-SJ and BF-SO for Pb²⁺/Mg²⁺ and Pb²⁺/Al³⁺ were as low as 31.23 μM, 25.95 μM, 59.57 μM and 1.38 μM, respectively. Ideally, they showed low cytotoxicity and were successfully used for imaging of exogenous Pb²⁺/Mg²⁺ and Pb²⁺/Al³⁺ in HeLa cells. Also, BF-SJ exhibited satisfactory performance in detection of Mg²⁺ in seawater and test paper experiment.

Graphical abstract

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通过 "开启 "响应实现 Pb2+、Mg2+ 和 Al3+ 离子多功能检测的 ESIPT 性能双希夫碱及其生物应用

选择苯并噻唑、肼/氨和水杨醛作为基本单元，构建了具有激发态分子内质子转移（ESIPT）特性的双希夫碱分子。在此基础上，开发出了具有 "开启 "荧光性能和高灵敏度的多功能荧光探针，可稳定、高效地检测生物和环境样品中的 Pb2+、Mg2+ 和 Al3+。其中，BF-SJ 能在不同 pH 值条件下区分 Pb2+ 和 Mg2+ 离子，而 BF-SO 则能通过不同的发射波长分离 Pb2+ 和 Al3+。更重要的是，在太阳光和紫外灯下，目标离子可随溶液颜色的变化而被肉眼分辨出来。BF-SJ 和 BF-SO 对 Pb2+/Mg2+ 和 Pb2+/Al3+ 的 LOD 值分别低至 31.23 μM、25.95 μM、59.57 μM 和 1.38 μM。理想情况下，它们显示出较低的细胞毒性，并成功地用于外源 Pb2+/Mg2+ 和 Pb2+/Al3+ 在 HeLa 细胞中的成像。此外，BF-SJ 在海水和试纸实验中检测 Mg2+ 的性能也令人满意。

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.