MCL1 inhibitor BRD-810 kills cancer cells while minimizing risk of cardiotoxicity

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-09-11 DOI:10.1038/s43018-024-00815-z

引用次数: 0

Abstract

The anti-apoptotic protein MCL1 is a therapeutic target in cancer, but long-term MCL1 inhibition has been found to increase the risk of cardiotoxicity. We developed BRD-810 as a potent and selective MCL1 inhibitor that induces cancer cell death in vivo within a few hours. As BRD-810 was designed to be rapidly cleared, it targets cancer cells while minimizing the risk for cardiotoxicity.

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MCL1抑制剂BRD-810可杀死癌细胞，同时最大程度降低心脏毒性风险

抗凋亡蛋白 MCL1 是癌症的治疗靶点，但长期抑制 MCL1 会增加心脏毒性的风险。我们开发的BRD-810是一种强效的选择性MCL1抑制剂，可在数小时内诱导体内癌细胞死亡。由于BRD-810可被迅速清除，因此它在靶向癌细胞的同时，也将心脏毒性的风险降到了最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.

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