Study on Eu3+-doped MgAl-LDH as carrier of chlorogenic acid and their fluorescent property

IF 2.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Iranian Chemical Society Pub Date : 2024-08-19 DOI:10.1007/s13738-024-03081-z

Xiaoqiang Shang, Tingting Li, Fang Guo, Yijun Liu, Yufeng Chen

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Abstract

Since drug release behavior depends on the interaction between the drugs and carriers, the present work is to study the drug delivery system based on magnesium aluminum layered double hydroxides containing europium (MgAl-Eu-LDH) for chlorogenic acid (CGA). Various characterizations, including X-ray diffraction (XRD), infrared spectrum, zeta potentials, UV–Vis absorption spectrum, scanning electron scanning electron microscope equipped with energy-dispersive X-ray spectroscopy (SEM–EDS), CHN elemental analysis, and fluorescent spectra, were employed to investigate the drug delivery system. Results revealed that the CGA was loaded into MgAl-Eu-LDH. The drug delivery system based on MgAl-Eu-LDH exhibited more slow and sustained release of CGA compared with that of the previous methotrexate or 5-fluorouracil, and the drug release experiment can be reproducible. Moreover, the MgAl-Eu-LDH showed different fluorescence before loading CGA, during loading CGA, and after releasing CGA. These results may provide a reference for the development of CGA drug delivery systems with slow and sustained release.

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作为绿原酸载体的 Eu3+ 掺杂 MgAl-LDH 及其荧光特性研究

由于药物释放行为取决于药物和载体之间的相互作用，本研究工作旨在研究基于含铕的镁铝层状双氢氧化物（MgAl-Eu-LDH）的绿原酸（CGA）给药系统。研究采用了多种表征方法，包括 X 射线衍射 (XRD)、红外光谱、ZETA 电位、紫外可见吸收光谱、配备能量色散 X 射线光谱仪的扫描电子显微镜 (SEM-EDS)、CHN 元素分析和荧光光谱，来研究该给药系统。结果表明，CGA 被负载在 MgAl-Eu-LDH 中。与之前的甲氨蝶呤或 5-氟尿嘧啶相比，基于 MgAl-Eu-LDH 的给药系统能更缓慢、更持久地释放 CGA，且药物释放实验具有可重复性。此外，MgAl-Eu-LDH 在装载 CGA 之前、装载 CGA 期间和释放 CGA 之后显示出不同的荧光。这些结果可为开发缓释和持续释放的 CGA 给药系统提供参考。

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.