Utilization of 2-cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide for the synthesis of thiazole, pyrazole and pyridene derivatives with a biological evaluation
Mohamed Ahmed Mahmoud Abdel Reheim, Ibrahim Saad Abdel Hafiz, Reem Mustafa Darweesh, Sayeda Abdelrazek Abdelhamid, Mohamed Ahmed Elian Sophy
{"title":"Utilization of 2-cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide for the synthesis of thiazole, pyrazole and pyridene derivatives with a biological evaluation","authors":"Mohamed Ahmed Mahmoud Abdel Reheim, Ibrahim Saad Abdel Hafiz, Reem Mustafa Darweesh, Sayeda Abdelrazek Abdelhamid, Mohamed Ahmed Elian Sophy","doi":"10.1007/s13738-024-03082-y","DOIUrl":null,"url":null,"abstract":"<div><p>A range of fused heterocyclic compounds are generated utilizing the crucial intermediary 2-cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide <b>4</b>. Spectral analysis was executed to support the structures of the newly synthesized compounds, which is expected to have a potential biological activity. The antimicrobial activity of the recently synthesized compounds and their derivatives has been tested against <i>B. subtilis, S. aureus, E. coli</i>, <i>P. aeruginosa, S. typhimurium, C. albicans, and A. niger,</i> as reference antibiotics, <i>ampicillin</i> and <i>mycostatin</i>, were used against test bacteria and fungi, respectively. In general, the novel produced compounds demonstrated a good antibacterial action against the previously indicated pathogens.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Iranian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13738-024-03082-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A range of fused heterocyclic compounds are generated utilizing the crucial intermediary 2-cyano-N-(2,5-dioxopyrrolidin-1-yl) acetamide 4. Spectral analysis was executed to support the structures of the newly synthesized compounds, which is expected to have a potential biological activity. The antimicrobial activity of the recently synthesized compounds and their derivatives has been tested against B. subtilis, S. aureus, E. coli, P. aeruginosa, S. typhimurium, C. albicans, and A. niger, as reference antibiotics, ampicillin and mycostatin, were used against test bacteria and fungi, respectively. In general, the novel produced compounds demonstrated a good antibacterial action against the previously indicated pathogens.
期刊介绍：
JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
