Does Periodontitis Increase the Risk for Future Cardiovascular Events? Long-Term Follow-Up of the PAROKRANK Study.

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2024-09-11 DOI:10.1111/jcpe.14064

Anna Norhammar,Per Näsman,Kåre Buhlin,Ulf de Faire,Giulia Ferrannini,Anders Gustafsson,Barbro Kjellström,Thomas Kvist,Eva Levring Jäghagen,Bertil Lindahl,Åke Nygren,Ulf Näslund,Elisabet Svenungsson,Björn Klinge,Lars Rydén,

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引用次数: 0

Abstract

BACKGROUND AND AIM The study 'Periodontitis and Its Relation to Coronary Artery Disease' (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD-compared to periodontally healthy individuals-are at increased risk for cardiovascular (CV) events and death. METHODS A total of 1587 participants (age <75 years; females 19%) had a dental examination including panoramic radiographs between 2010 and 2014. PD was categorized as healthy (≥80% alveolar bone height), mild/moderate (79%-66%) or severe (<66%). A composite CV event (first of all-cause death, non-fatal MI or stroke and hospitalization following to heart failure) was investigated during a mean follow-up period of 9.9 years (range 0.2-12.5 years). Participants were divided into two groups: those with and without PD. The primary event rate, stratified by periodontal status at baseline, was calculated using the Kaplan-Meier method and Cox regression. RESULTS The number of events was 187 in the 985 periodontally healthy participants (19%) and 174 in the 602 participants with PD (29%; p < 0.0001). Those with PD had a higher likelihood for a future event (hazard ratio [HR] = 1.26; 95% CI: 1.01-1.57; p = 0.038), following adjustment for age, smoking and diabetes. CONCLUSION The PAROKRANK follow-up revealed that CV events were more common among participants with PD, which supports the assumption that there might be a direct relation between PD and CV disease.

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牙周炎会增加未来心血管事件的风险吗？PAROKRANK研究的长期随访。

背景和目的 "牙周炎及其与冠状动脉疾病的关系"（PAROKRANK）研究报告了牙周炎（PD）与首次心肌梗塞（MI）之间的关系。本后续研究旨在验证以下假设：与牙周健康的人相比，患有牙周炎的人发生心血管（CV）事件和死亡的风险更高。方法共有 1587 名参与者（年龄小于 75 岁；女性占 19%）在 2010 年至 2014 年期间进行了牙科检查，包括全景 X 光片。牙周病分为健康（牙槽骨高度≥80%）、轻度/中度（79%-66%）或重度（<66%）。在平均 9.9 年（0.2-12.5 年）的随访期间，对复合心血管事件（首次全因死亡、非致命性心肌梗死或中风以及心力衰竭住院）进行了调查。参与者被分为两组：有和没有帕金森病的患者。结果985名牙周健康的参与者中发生了187起事件（19%），602名患有帕金森病的参与者中发生了174起事件（29%；P < 0.0001）。在对年龄、吸烟和糖尿病等因素进行调整后，患有牙周病的参与者未来发生事件的可能性更高（危险比 [HR] = 1.26；95% CI：1.01-1.57；p = 0.038）。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.