Jacqueline Córdova-Gallardo, Froylan David Martínez-Sánchez, David Medina-Julio, Martin Edgardo Rojano-Rodríguez, Luz Sujey Romero-Loera, Romina Vargas-Agredano, Nahum Méndez-Sánchez
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Abstract
Background
Obesity is a significant risk factor for metabolic-associated steatotic liver disease (MASLD). The association between Helicobacter pylori (HP) infection and liver fibrosis has not been fully elucidated in patients with obesity and MASLD.
Methods
This observational retrospective study included clinical and biochemical parameters of patients with obesity undergoing bariatric surgery. HP infection was confirmed by gastric endoscopy, and liver biopsies were performed during surgery. Bivariate and logistic regression analyses were employed to evaluate independent associations with liver fibrosis and steatosis by biopsy.
Results
The mean age of the subjects was 42 ± 10 years, with 84.7% being women, and they had a mean BMI of 42.97 ± 7.56 kg/m2. Overall, 41.7% of patients had an HP infection. Multiple logistic regression models were conducted to assess the association between HP infection, liver steatosis, and fibrosis by biopsy. HP infection was independently associated with liver fibrosis [OR = 3.164 (95% CI 1.011–9.900)].
Conclusion
Biopsy findings associated HP infection with increased liver fibrosis.
背景 肥胖是代谢相关性脂肪性肝病（MASLD）的重要危险因素。在肥胖症和代谢相关性脂肪性肝病患者中，幽门螺杆菌（HP）感染与肝纤维化之间的关系尚未完全阐明。 方法 这项观察性回顾研究包括接受减肥手术的肥胖症患者的临床和生化指标。胃内镜检查证实了 HP 感染，手术过程中进行了肝活检。采用二元和逻辑回归分析评估活检结果与肝纤维化和脂肪变性之间的独立关联。 结果 受试者的平均年龄为（42 ± 10）岁，84.7%为女性，平均体重指数为（42.97 ± 7.56）kg/m2。总体而言，41.7%的患者有 HP 感染。研究人员采用多元逻辑回归模型评估了 HP 感染、肝脏脂肪变性和活组织检查纤维化之间的关联。HP感染与肝纤维化独立相关[OR = 3.164 (95% CI 1.011-9.900)]。 结论 活检结果显示 HP 感染与肝纤维化增加有关。
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