Community-Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environmental Contaminants

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-09-12 DOI:10.1002/bdr2.2395

Marilyn Silva, Shosha Capps, Jonathan K. London

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引用次数: 0

Abstract

Background

The paper analyzes opportunities for integrating Open access resources (Abstract Sifter, US EPA and NTP Toxicity Value and Toxicity Reference [ToxVal/ToxRefDB]) and New Approach Methodologies (NAM) integration into Community Engaged Research (CEnR).

Methods

CompTox Chemicals Dashboard and Integrated Chemical Environment with in vivo ToxVal/ToxRef and NAMs (in vitro) databases are presented in three case studies to show how these resources could be used in Pilot Projects involving Community Engaged Research (CEnR) from the University of California, Davis, Environmental Health Sciences Center.

Results

Case #1 developed a novel assay methodology for testing pesticide toxicity. Case #2 involved detection of water contaminants from wildfire ash and Case #3 involved contaminants on Tribal Lands. Abstract Sifter/ToxVal/ToxRefDB regulatory data and NAMs could be used to screen/prioritize risks from exposure to metals, PAHs and PFAS from wildfire ash leached into water and to investigate activities of environmental toxins (e.g., pesticides) on Tribal lands. Open access NAMs and computational tools can apply to detection of sensitive biological activities in potential or known adverse outcome pathways to predict points of departure (POD) for comparison with regulatory values for hazard identification. Open access Systematic Empirical Evaluation of Models or biomonitoring exposures are available for human subpopulations and can be used to determine bioactivity (POD) to exposure ratio to facilitate mitigation.

Conclusions

These resources help prioritize chemical toxicity and facilitate regulatory decisions and health protective policies that can aid stakeholders in deciding on needed research. Insights into exposure risks can aid environmental justice and health equity advocates.

查看原文本刊更多论文

社区参与研究以及使用开放式 ToxVal/ToxRef 活体数据库和新方法 (NAM) 解决环境污染物对人类健康造成的风险问题

背景本文分析了将开放存取资源（Abstract Sifter、US EPA 和 NTP 毒性值和毒性参考 [ToxVal/ToxRefDB]）和新方法 (NAM) 整合到社区参与研究 (CEnR) 中的机会。方法在三个案例研究中介绍了 CompTox 化学品仪表板和集成化学环境，以及体内 ToxVal/ToxRef 和 NAMs（体外）数据库，以说明如何将这些资源用于加州大学戴维斯分校环境健康科学中心的社区参与研究 (CEnR) 试点项目。结果案例 1 开发了一种用于检测农药毒性的新型检测方法。案例 2 涉及检测野火灰烬中的水污染物，案例 3 涉及部落土地上的污染物。摘要 Sifter/ToxVal/ToxRefDB 监管数据和 NAMs 可用于筛选/优先处理野火灰烬浸入水中的金属、多环芳烃和全氟辛烷磺酸的暴露风险，以及调查部落土地上环境毒素（如农药）的活动。开放存取的 NAM 和计算工具可用于检测潜在或已知不利结果途径中的敏感生物活动，以预测出发点 (POD)，并与监管值进行比较，从而确定危害。开放存取的系统经验评估模型或生物监测暴露可用于人类亚群，并可用于确定生物活性（POD）与暴露的比率，以促进缓解。结论这些资源有助于确定化学品毒性的优先次序，促进监管决策和健康保护政策的制定，从而帮助利益相关者决定所需的研究。对暴露风险的深入了解有助于环境正义和健康公平的倡导者。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.