Phytochemical characterization and evaluation of anti-amnesic activity of two source plants of Shankhapushpi

Brain Behavior and Immunity Integrative Pub Date : 2024-09-12 DOI:10.1016/j.bbii.2024.100085

Sulaiman C.T., Jyothi C.K., Jinu Krishnan Unnithan G., Prabhukumar K.M., Indira Balachandran

{"title":"Phytochemical characterization and evaluation of anti-amnesic activity of two source plants of Shankhapushpi","authors":"Sulaiman C.T., Jyothi C.K., Jinu Krishnan Unnithan G., Prabhukumar K.M., Indira Balachandran","doi":"10.1016/j.bbii.2024.100085","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><em>Shankhapushpi</em> is an important Ayurvedic drug used for treating various disease conditions of nervous system. <em>Convolvulus prostratus</em> Forssk. is the genuine source plant for <em>Shankhapushpi</em> as per Ayurvedic Pharmacopoeia of India; however <em>Clitorea ternatea</em> L. is widely used as <em>Shankhapushpi</em> in southern part of India. In this study, comparative phytochemical and pharmacological evaluation has been done in two plants such as <em>Convolvulus prostratus</em> and <em>Clitorea ternatea</em> used as <em>Shankhapushpi</em>.</p></div><div><h3>Methods</h3><p>Phytochemical comparison was done by High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC). Detailed metabolite profiling was performed using Q-TOF-LC/MS-MS analysis. Antiamnesic activity of selected plants has been evaluated against scopolamine induced amnesia model in Wistar rats.</p></div><div><h3>Results</h3><p>Phytochemical studies showed that only a few chemical constituents are common for both species. Most of the phytochemicals are different for selected species. LC/MS analysis showed presence of genipin and 7-hydroxyflavone in both species. Pharmacological study showed that both plants possess antiamnesic activity against Scopolamine induced memory loss; However <em>C. ternatea</em> possesses significant antiamnesic activity than that of <em>C. prostratus</em>.</p></div><div><h3>Conclusion</h3><p>The study provided valuable information about the selected species in terms of its phytochemical composition and pharmacological properties. The study also provided a scientific support for using both species as <em>Shankhapushpi</em>.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"8 ","pages":"Article 100085"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834124000412/pdfft?md5=5abe2e361c2d1b80578b83c74e25d032&pid=1-s2.0-S2949834124000412-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Behavior and Immunity Integrative","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949834124000412","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Shankhapushpi is an important Ayurvedic drug used for treating various disease conditions of nervous system. Convolvulus prostratus Forssk. is the genuine source plant for Shankhapushpi as per Ayurvedic Pharmacopoeia of India; however Clitorea ternatea L. is widely used as Shankhapushpi in southern part of India. In this study, comparative phytochemical and pharmacological evaluation has been done in two plants such as Convolvulus prostratus and Clitorea ternatea used as Shankhapushpi.

Methods

Phytochemical comparison was done by High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC). Detailed metabolite profiling was performed using Q-TOF-LC/MS-MS analysis. Antiamnesic activity of selected plants has been evaluated against scopolamine induced amnesia model in Wistar rats.

Results

Phytochemical studies showed that only a few chemical constituents are common for both species. Most of the phytochemicals are different for selected species. LC/MS analysis showed presence of genipin and 7-hydroxyflavone in both species. Pharmacological study showed that both plants possess antiamnesic activity against Scopolamine induced memory loss; However C. ternatea possesses significant antiamnesic activity than that of C. prostratus.

Conclusion

The study provided valuable information about the selected species in terms of its phytochemical composition and pharmacological properties. The study also provided a scientific support for using both species as Shankhapushpi.

查看原文本刊更多论文

香卡普什皮两种来源植物的植物化学特征和抗失水活性评估

背景Shankhapushpi是一种重要的阿育吠陀药物，用于治疗神经系统的各种疾病。根据印度阿育吠陀药典，Convolvulus prostratus Forssk.是 Shankhapushpi 的真正来源植物；但在印度南部地区，Clitorea ternatea L. 被广泛用作 Shankhapushpi。本研究对用作 Shankhapushpi 的 Convolvulus prostratus 和 Clitorea ternatea 这两种植物进行了植物化学和药理评估比较。使用 Q-TOF-LC/MS-MS 分析法进行了详细的代谢物分析。评估了所选植物对东莨菪碱诱导的 Wistar 大鼠健忘症模型的抗健忘活性。大多数植物化学成分在所选物种中是不同的。LC/MS 分析表明，两种植物中都含有玄参素和 7-羟基黄酮。药理研究表明，这两种植物都具有抗东莨菪碱引起的记忆力减退的活性；但 C. ternatea 的抗记忆力活性明显高于 C. prostratus。该研究还为将这两种植物用作香卡普希皮提供了科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Behavior and Immunity Integrative

自引率

0.00%

发文量