Biliary stents for active materials and surface modification: Recent advances and future perspectives

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-09-13 DOI:10.1016/j.bioactmat.2024.08.031

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Abstract

Demand for biliary stents has expanded with the increasing incidence of biliary disease. The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures. However, these stents are nondegradable and prone to restenosis. Surgical removal or replacement of the nondegradable stents is necessary in cases of disease resolution or restenosis. To overcome these shortcomings, improvements were made to the materials and surfaces used for the stents. First, this paper reviews the advantages and limitations of nondegradable stents. Second, emphasis is placed on biodegradable polymer and biodegradable metal stents, along with functional coatings. This also encompasses tissue engineering & 3D-printed stents were highlighted. Finally, the future perspectives of biliary stents, including pro-epithelialization coatings, multifunctional coated stents, biodegradable shape memory stents, and 4D bioprinting, were discussed.

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用于活性材料和表面改性的胆道支架：最新进展与未来展望

随着胆道疾病发病率的增加，胆道支架的需求也随之扩大。植入塑料或可自行扩张的金属支架可有效治疗胆道狭窄。然而，这些支架是不可降解的，容易发生再狭窄。在疾病缓解或再狭窄的情况下，必须通过手术取出或更换不可降解的支架。为了克服这些缺点，人们对支架的材料和表面进行了改进。首先，本文回顾了不可降解支架的优点和局限性。其次，重点介绍可生物降解聚合物和可生物降解金属支架以及功能涂层。这也包括组织工程和ampamp；重点介绍了三维打印支架。最后，讨论了胆道支架的未来前景，包括促上皮化涂层、多功能涂层支架、生物可降解形状记忆支架和 4D 生物打印。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.

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