Effectiveness of cardiometabolic index, lipid accumulation product, visceral adiposity index and waist-to-thigh ratio for the early diagnosis of diabetes in young females at childbearing age who were obese or non-obese

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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引用次数: 0

Abstract

Aim

To explore the effectiveness of the cardiometabolic index (CMI), lipid accumulation product (LAP), and waist-to-thigh ratio (WTR) in identifying insulin resistance (IR) in females who are clinically not having diabetes mellitus (DM).

Methods

This cross-sectional study was conducted in Sri Lanka between 2020 and 2023. A total of 282 female participants aged 18 to 35 were recruited. Their anthropometric measurements, fasting blood sugar (FBS) levels, IR by HOMA-IR, lipid profile, and blood pressure were assessed. All females with FBS levels >100 mg/dl were excluded from the study.

Results

The study participants were divided into two groups, normal-weight controls (N = 142, BMI:18.0–22.9 kg/m2) and overweight/obese cases (N = 140, BMI:23.0–24.9 kg/m2, Obesity: >25 kg/m2), based on their BMI values. The mean values of CMI, LAP, and WTR in cases were 3.56 ± 0.63, 49.97 ± 17.75, and 1.88 ± 0.17, respectively. Significant associations were identified between all adiposity indexes, IR and lipid profile parameters (p < 0.05). In this female cohort, despite being clinically non DM, the prevalence of IR was significantly higher (52.83 %). ROC analysis results showed greater sensitivities for detecting IR with higher AUC as follows: CMI = 0.854(0.811–0.899), LAP = 0.869(0.829–0.910), and WTR = 0.828(0.779–0.877). The normal-weight controls were assessed to check the prevalence of metabolically-obese normal-weights (MONW,65.5 %) and metabolically-healthy normal-weights (MHNW,35.5 %) among the population, given the higher prevalence of IR. The detection accuracy of MONW females in the ROC assay was; CMI > LAP > WTR > VAI.

Conclusions

CMI had the highest accuracy for detecting IR, with the accuracy of all four indexes ranked as follows: CMI > LAP > WTR > VAI.

肥胖或非肥胖育龄年轻女性的心脏代谢指数、脂质累积乘积、内脏脂肪指数和腰围与大腿比例对早期诊断糖尿病的效果
目的探讨心血管代谢指数(CMI)、脂质累积乘积(LAP)和腰围与大腿比例(WTR)在识别临床上未患糖尿病(DM)的女性胰岛素抵抗(IR)方面的有效性。 方法这项横断面研究于 2020 年至 2023 年在斯里兰卡进行。共招募了 282 名年龄在 18 至 35 岁之间的女性参与者。研究人员对她们的人体测量指标、空腹血糖(FBS)水平、HOMA-IR 法测定的IR、血脂状况和血压进行了评估。结果根据体重指数值,研究对象被分为两组,正常体重对照组(142 人,体重指数:18.0-22.9 kg/m2)和超重/肥胖组(140 人,体重指数:23.0-24.9 kg/m2,肥胖:25 kg/m2)。病例的 CMI、LAP 和 WTR 平均值分别为 3.56 ± 0.63、49.97 ± 17.75 和 1.88 ± 0.17。所有脂肪指数、IR 和血脂谱参数之间均存在显著关联(p < 0.05)。在该女性队列中,尽管临床上不属于 DM,但 IR 的患病率明显更高(52.83%)。ROC 分析结果显示,检测 IR 的灵敏度更高,AUC 更高,如下所示:CMI = 0.854(0.811-0.899),LAP = 0.869(0.829-0.910),WTR = 0.828(0.779-0.877)。对正常体重对照组进行了评估,以检查代谢性肥胖正常体重者(MONW,65.5%)和代谢健康正常体重者(MHNW,35.5%)在人群中的患病率,因为红外患病率较高。在 ROC 检测中,MONW 女性的检测准确率为:CMI > LAP > WTR > VAI.结论CMI 检测 IR 的准确率最高,所有四项指标的准确率排名如下:CMI > LAP > WTR > VAI:CMI > LAP > WTR > VAI。
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来源期刊
Clinical Epidemiology and Global Health
Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
4.60
自引率
7.70%
发文量
218
审稿时长
66 days
期刊介绍: Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.
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