Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics: X Pub Date : 2024-09-10 DOI:10.1016/j.ijpx.2024.100283

Md. Anamul Haque , Archana Shrestha , Constantinos M. Mikelis , George Mattheolabakis

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Abstract

Nucleic acid-based therapeutics are a common approach that is increasingly popular for a wide spectrum of diseases. Lipid nanoparticles (LNPs) are promising delivery carriers that provide RNA stability, with strong transfection efficiency, favorable and tailorable pharmacokinetics, limited toxicity, and established translatability. In this review article, we describe the lipid-based delivery systems, focusing on lipid nanoparticles, the need of their use, provide a comprehensive analysis of each component, and highlight the advantages and disadvantages of the existing manufacturing processes. We further summarize the ongoing and completed clinical trials utilizing LNPs, indicating important aspects/questions worth of investigation, and analyze the future perspectives of this significant and promising therapeutic approach.

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用于递送 RNA 的脂质纳米粒子配方和制备的综合分析

基于核酸的疗法是一种常见的方法，在治疗各种疾病方面越来越受欢迎。脂质纳米颗粒（LNPs）是一种很有前景的递送载体，它具有 RNA 稳定性、转染效率高、药代动力学良好且可定制、毒性有限、可转化性强等特点。在这篇综述文章中，我们介绍了基于脂质的递送系统，重点是脂质纳米颗粒及其使用需求，全面分析了每种成分，并强调了现有生产工艺的优缺点。我们进一步总结了正在进行和已经完成的利用 LNPs 的临床试验，指出了值得研究的重要方面/问题，并分析了这种重要而有前景的治疗方法的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

24 days

期刊介绍： International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.