Clostridial gas gangrene involving the brain, gallbladder, heart, and soft tissue: A case report and literature review

IF 1.1 Q4 INFECTIOUS DISEASES

IDCases Pub Date : 2024-01-01 DOI:10.1016/j.idcr.2024.e02073

Ashton D. Hall , Joshua M. Ferreri , Jennifer E. Baker , Eleanor A. Powell , Imran Ahmed , Timothy T. Klostermeier , Keith M. Luckett

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Abstract

Clostridial gas gangrene (CGG) is among the most rapidly spreading infections in humans, with mortality rates approaching 100 % if not treated promptly. Most cases follow traumatic inoculation, although spontaneous infections occur in a minority of patients with immunodeficiency. Spontaneous CGG is primarily caused by Clostridium septicum, whereas traumatic infection is associated with Clostridium perfringens. Patients with CGG present abruptly with rapidly progressive symptoms, underscoring the importance of early recognition, prompt surgical intervention, and appropriate antimicrobial therapy. We describe an illustrative case of spontaneous CGG caused by C. perfringens in a polymorbid 73-year-old female patient. Despite aggressive medical and surgical management, she succumbed to metastatic infection within 48 h of presentation.

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累及大脑、胆囊、心脏和软组织的梭状芽孢杆菌气性坏疽：病例报告和文献综述

梭状芽孢杆菌气性坏疽（CGG）是人类传播最迅速的感染之一，如不及时治疗，死亡率接近 100%。大多数病例是在外伤接种后发生的，但也有少数免疫缺陷患者发生自发感染。自发性 CGG 主要由败血梭菌引起，而外伤感染则与产气荚膜梭菌有关。CGG 患者发病突然，症状进展迅速，因此强调早期识别、及时手术干预和适当抗菌治疗的重要性。我们描述了一例由产气荚膜梭菌引起的自发性 CGG 病例，患者是一名 73 岁的多病女性。尽管进行了积极的内科和外科治疗，她还是在发病 48 小时内死于转移性感染。

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