Enhancing intracellular cholesterol efflux in chondrocytes alleviates osteoarthritis progression

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-09-11 DOI:10.1002/art.42984

Gyuseok Lee, Jiye Yang, Su-Jin Kim, Thanh-Tam Tran, Sun Young Lee, Ka Hyon Park, Seung-Hee Kwon, Ki-Ho Chung, Jeong-Tae Koh, Yun Hyun Huh, Jong-Keun Seon, Hyun Ah Kim, Jang-Soo Chun, Je-Hwang Ryu

引用次数: 0

Abstract

Osteoarthritis (OA) is the most common degenerative disease worldwide with no practical means of prevention and limited treatment options. Recently, our group unveiled a novel mechanism contributing to OA pathogenesis in association with abnormal cholesterol metabolism in chondrocytes. In this study, we aimed to establish a clinical link between lipid profiles and OA in humans, assess the effectiveness of cholesterol-lowering drugs in suppressing OA development in mice, and uncover the cholesterol-lowering mechanisms that effectively impede OA progression.

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增强软骨细胞细胞内胆固醇外流可缓解骨关节炎的进展

骨关节炎（OA）是全球最常见的退行性疾病，目前尚无切实可行的预防方法，治疗方案也很有限。最近，我们的研究小组发现了一种导致 OA 发病的新机制，它与软骨细胞中胆固醇代谢异常有关。在这项研究中，我们的目标是建立血脂状况与人类 OA 之间的临床联系，评估降低胆固醇药物抑制小鼠 OA 发生的有效性，并揭示有效阻碍 OA 进展的降低胆固醇机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.