Blood profile indicates central inflammation in frontotemporal lobar degeneration

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2024-09-12 DOI:10.1038/s41582-024-01021-2

Ian Fyfe

引用次数: 0

Abstract

A pro-inflammatory serum profile has been associated with frontotemporal lobar degeneration (FLTD) in new research, increasing the likelihood that blood-based biomarkers can be used for assessment of neuroinflammation in people with dementia. The researchers analysed cytokines in the serum of 214 people with syndromes associated with FTLD and 29 healthy individuals. Their analysis identified a profile of pro-inflammatory cytokines that was associated with FLTD. Stronger expression of this serum profile was associated with greater central neuroinflammation, as indicated by evidence of microglial activation on PET imaging, and with shorter survival.

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血液特征显示额颞叶变性的中枢炎症

新研究发现，促炎性血清特征与额颞叶变性（Frontotemporal lobar degeneration，FLTD）有关，这增加了用血液生物标记物评估痴呆症患者神经炎症的可能性。研究人员分析了214名患有FTLD相关综合征的患者和29名健康人血清中的细胞因子。他们的分析确定了一种与FLTD相关的促炎细胞因子特征。这种血清特征的强烈表达与更严重的中枢神经炎症（PET 成像显示小胶质细胞活化）和更短的存活期有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.

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