Free DNA activates secondary stroke mechanism

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2024-09-12 DOI:10.1038/s41582-024-01020-3

Ian Fyfe

引用次数: 0

Abstract

After a stroke, circulating, cell-free DNA causes inflammasome activation in atherosclerotic plaques that can lead to recurrent stroke, work in a mouse model has shown. In a model of stroke-induced recurrent ischaemia, increased inflammation in plaques in the common carotid artery resulted from activation of the AIM2 inflammasome by cell-free DNA that primarily originated from neutrophil extracellular traps (NETs). The increased inflammation led to plaque rupture and a secondary stroke. Administration of DNase after stroke reduced the risk of recurrent events in the mice, suggesting that this mechanism could be targeted therapeutically.

查看原文本刊更多论文

游离 DNA 激活二级中风机制

一项在小鼠模型中进行的研究表明，中风后，循环中的无细胞DNA会导致动脉粥样硬化斑块中的炎性体被激活，从而导致中风复发。在中风诱发的复发性缺血模型中，主要来自中性粒细胞胞外捕获物（NET）的无细胞DNA激活了AIM2炎性体，导致颈总动脉斑块中的炎症加剧。炎症的加剧导致斑块破裂和继发性中风。中风后服用DNase可降低小鼠再次发生中风的风险，这表明这种机制可以作为治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.

文献相关原料

公司名称	产品信息	采购帮参考价格