A new player in the biogenesis of lysosome-related organelles.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-09-11 DOI:10.1083/jcb.202407194

Anbing Shi

引用次数: 0

Abstract

How are Rab GTPases regulated during lysosome-related organelle (LRO) biogenesis? Li et al. (https://doi.org/10.1083/jcb.202402016) identify LYSMD proteins as crucial activators of Rab32-family GTPases in LRO development, shedding light on the previously ambiguous mechanisms governing Rab functionality in this process.

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溶酶体相关细胞器生物生成过程中的新角色。

在溶酶体相关细胞器（LRO）的生物发生过程中，Rab GTP酶是如何被调控的？Li等人（https://doi.org/10.1083/jcb.202402016）发现LYSMD蛋白是Rab32家族GTP酶在溶酶体相关细胞器发育过程中的关键激活剂，从而揭示了之前在这一过程中Rab功能的模糊机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.