Nonwoven-fabric-based microfluidic devices for solution viscosity measurements†

IF 3.5 Q2 CHEMISTRY, ANALYTICAL
Mayumi Otoba Uno, Mariko Omori and Kenji Sakamoto
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Abstract

Microfluidic chips designed to measure viscosity with extremely small amounts of liquids are expected to examine biological fluids, such as for the prediction of disease states and stress assessment, and for the evaluation of the physical properties of novel synthetic materials. However, these devices typically require sample volumes of several tens of μL or more, which has limitations when collecting biological samples from individuals nearly non-invasively. In this study, we fabricated a flow channel on a nonwoven fabric substrate with tailored hydrophilic and hydrophobic properties to enable viscosity measurements with the small-volume flow of aqueous solutions, such as 3 μL of saline. By measuring the electrical conductivity of the liquid using comb-shaped printed electrodes in contact with the flow path, we quantified the time and distance of liquid flow driven by capillary action to estimate solution viscosity. Using a mixture of glycerol and saline solution with varying viscosities, while maintaining a constant ion concentration, we demonstrated the capability to assess the relative viscosity of solutions. This was achieved by evaluating the correlation coefficient between the flow time and distance, and the net electrical conductivity, which is influenced by the viscosity and ion concentration of the solutions. This study lays the groundwork for developing a low-cost technique to measure the viscosity of solutions with a few μL, offering potential for routine health monitoring and disease prevention.

Abstract Image

用于溶液粘度测量的基于无纺布的微流控装置†。
用于测量极微量液体粘度的微流控芯片有望用于检查生物液体,如预测疾病状态和压力评估,以及评估新型合成材料的物理性质。然而,这些设备通常需要几十微升或更多的样本量,这对近乎无创地采集个人生物样本造成了限制。在这项研究中,我们在无纺布基底上制作了一个具有定制亲水和疏水特性的流道,以便能用小体积的水溶液(如 3 μL 的生理盐水)流进行粘度测量。通过使用与流动路径接触的梳状印刷电极测量液体的导电性,我们量化了毛细作用驱动液体流动的时间和距离,从而估算出溶液的粘度。我们使用不同粘度的甘油和生理盐水混合物,同时保持恒定的离子浓度,展示了评估溶液相对粘度的能力。这是通过评估流动时间和距离与净电导率之间的相关系数实现的,而净电导率受溶液粘度和离子浓度的影响。这项研究为开发一种测量几微升溶液粘度的低成本技术奠定了基础,为常规健康监测和疾病预防提供了潜力。
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来源期刊
CiteScore
2.30
自引率
0.00%
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