Modeling conjugate vaccine and natural induced antibody correlates of protection for pneumococcal colonization and acute otitis media infection in young children

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2024-09-11 DOI:10.1016/j.vaccine.2024.126295

Minh Pham , Michael Pichichero

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Abstract

We measured anti-pneumococcal serotype 19A vaccine-induced antibodies in 160 children (611 sera) after introduction of 13-valent pneumococcal conjugate vaccine and naturally-induced antibodies in 59 children (185 sera) after colonization and acute otitis media (AOM) episodes caused by strains expressing serotype 19A. Correlate of protection (COP) models were constructed using results from multiple prospectively-collected observations in individual children. Generalized estimating equations followed by logistic-regression was used. The COP derived from vaccine-induced antibody levels for prevention of colonization was 5 μg/mL and for AOM was 2.3 μg/mL. A COP for naturally-induced antibody levels for prevention of colonization or AOM could not be derived because an age gradient was not observed. Combining natural- and vaccine-induced antibody levels did not provide biologically plausible COP estimates. We conclude derivation of a COP for prevention of colonization and AOM using individual multi-point child data for pneumococcal serotype 19A can be estimated when an age-gradient is observed.

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建立共轭疫苗和自然诱导抗体对幼儿肺炎球菌定植和急性中耳炎感染的保护相关性模型

我们测量了 160 名儿童（611 份血清）在接种 13 价肺炎球菌结合疫苗后产生的抗肺炎球菌血清型 19A 疫苗诱导抗体，以及 59 名儿童（185 份血清）在由表达血清型 19A 的菌株引起的定植和急性中耳炎 (AOM) 发作后产生的自然诱导抗体。保护相关性（COP）模型是利用对个别儿童的多次前瞻性观察结果构建的。使用了广义估计方程和逻辑回归。根据疫苗诱导抗体水平得出的预防定植的 COP 为 5 μg/mL，预防 AOM 的 COP 为 2.3 μg/mL。由于未观察到年龄梯度，因此无法得出预防定植或 AOM 的自然诱导抗体水平 COP。将自然和疫苗诱导的抗体水平结合起来，也无法得出生物学上合理的 COP 估计值。我们的结论是，在观察到年龄梯度的情况下，可以利用肺炎球菌血清型 19A 的多点儿童个体数据估算出预防定植和 AOM 的 COP。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.