A multi-adjuvant nanovaccine platform based on targeted delivery of specific antigens for cancer immunotherapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today Pub Date : 2024-09-11 DOI:10.1016/j.nantod.2024.102481

Wen Li, Qiu-Ling Zhang, Xiang-Yu Ma, Xuan Zeng, Xian-Zheng Zhang

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Abstract

Cancer vaccines have become a milestone in immunotherapy, but inadequate activation rate of antigen presenting cells (APCs) and low delivery efficiency of specific antigen have widely limited their clinical application. Here we design an engineered vaccine platform based on targeted delivery of specific antigens to activated APCs. This vaccine platform is implemented by loading an agonist for stimulator of interferon genes and tumor lysate protein with calcium phosphate as adjuvants, and coating the surface with mannose-modified liposomes. By loading different types of tumor antigen proteins, this nanovaccine platform successfully achieves tumor immunotherapy in breast and colon cancer bearing mice. In addition, personalized nanovaccine prepared from surgically removed tumor lysate proteins also significantly suppresses postsurgical distant tumor. Through the design of nanovaccine platform, we provide an efficient multi-adjuvant delivery platform for multiple types of tumor antigens, and also offer more ideas for personalized vaccine immunization. This nanovaccine platform has great prospects for transformation due to the designability and simplicity for the preparation.

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基于特定抗原靶向递送的多辅助纳米疫苗平台，用于癌症免疫疗法

癌症疫苗已成为免疫疗法的一个里程碑，但抗原呈递细胞（APC）活化率不足和特异性抗原递送效率低普遍限制了其临床应用。在此，我们设计了一种基于向活化的抗原呈递细胞定向递送特异性抗原的工程疫苗平台。这种疫苗平台的实现方法是：以磷酸钙为佐剂，加入刺激干扰素基因的激动剂和肿瘤裂解蛋白，并在其表面涂上甘露糖修饰的脂质体。通过负载不同类型的肿瘤抗原蛋白，该纳米疫苗平台成功实现了对乳腺癌和结肠癌小鼠的肿瘤免疫治疗。此外，用手术切除的肿瘤裂解蛋白制备的个性化纳米疫苗也能显著抑制手术后的远处肿瘤。通过纳米疫苗平台的设计，我们为多种类型的肿瘤抗原提供了一个高效的多辅助给药平台，也为个性化疫苗免疫提供了更多的思路。该纳米疫苗平台的可设计性和制备的简便性使其具有广阔的转化前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Today 工程技术-材料科学：综合

CiteScore

21.50

自引率

3.40%

发文量

305

审稿时长

40 days

期刊介绍： Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.