Stress less: Viral mastery of the RNA G-quadruplex

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-09-11 DOI:10.1016/j.chom.2024.08.011

Sheila Gonzalez, Maria G. Noval, Jessica M. Tucker

引用次数: 0

Abstract

RNA G-quadruplexes are dynamically regulated during stress and infection. In this issue of Cell Host & Microbe, Schult et al.¹ demonstrate that an RNA G-quadruplex conserved across orthoflaviviruses binds hnRNPH1 to mitigate the host stress response, highlighting the potential of this dynamic proviral RNA structure as a pan-flaviviral target.

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减轻压力：病毒驾驭 RNA G 型四联体

RNA G-四链体在应激和感染过程中受到动态调节。在本期《细胞宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Schult 等人1 证明了一种在正黄病毒中保留下来的 RNA G-四链体能与 hnRNPH1 结合，从而减轻宿主的应激反应，凸显了这种动态前病毒 RNA 结构作为泛黄病毒靶标的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.