MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan

Abstract

EFFECT OF AGE ON (A) CBF, (B) ATT, AND (D) FA, WHERE (C) DEMONSTRATES THE OVERLAY OF THE CBF AND ATT MAPS FOR ASSOCIATIONS WITH AGE. RESULTS ARE PRESENTED AFTER MULTIPLE COMPARISONS CORRECTION (PTFCE < 0.05) AND CONTROLLING FOR SEX. MORE WIDESPREAD ASSOCIATIONS WITH AGE ARE PREVALENT FOR ATT IN COMPARISON WITH CBF. DICE COEFFICIENT BETWEEN CBF DECREASING WITH AGE AND ATT INCREASING WITH AGE UPON THRESHOLDING AT PFWE < 0.05 = 0.8045, INDICATING HIGH OVERLAP OF THESE MEASURES OF HEMODYNAMICS. LOWER FA WAS GENERALLY ASSOCIATED WITH INCREASING AGE, THOUGH HIGHER FA WAS ASSOCIATED WITH INCREASING AGE IN THE SURROUNDING RETROLENTICULAR PART OF THE INTERNAL CAPSULE. BY DAMESTANI ET AL. (1549–1562)