The effect of common parameters of bipolar stimulation on brain evoked potentials

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-08-31 DOI:10.1016/j.clinph.2024.08.019

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引用次数: 0

Abstract

Objective

To identify optimal bipolar stimulation parameters for robust generation of brain evoked potentials (BEPs), namely the interelectrode distance (IED) and the intensity of stimulation (IS), in cortical and axonal stimulation.

Methods

In 15 patients who underwent awake surgery for brain tumor removal, BEPs were elicited at different values of IED and IS, respectively: 5 mm-5 mA, 5 mm-10 mA, and 10 mm-10 mA. The number of BEPs elicited by stimulation, as well as the delays and amplitudes of the N1 waves were compared between the different groups of stimulation parameters and according to the stimulated brain structure (cortical vs. axonal).

Results

The amplitudes of N1 increased with the intensity of bipolar stimulation, either in cortical or axonal stimulation, while N1 peak delays were not affected by the stimulation parameters. Furthermore, axonal stimulation produced more N1s than cortical stimulation, with lower latencies.

Conclusions

Understanding the relationship between stimulation parameters and BEP is of utmost importance to determine whether the generated N1 waves accurately reflect the underlying structural anatomy. Other factors, such as stimulation frequency or pulse width and shape, may also play a role and warrant further investigation.

Significance

This study represents the first step in describing the influence of common bipolar stimulation parameters on robustness of BEPs by examining the impact of IED and IS on the N1 wave.

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双极刺激的常见参数对大脑诱发电位的影响

目的确定在皮层和轴突刺激中产生脑诱发电位（BEPs）的最佳双极刺激参数，即电极间距（IED）和刺激强度（IS）。方法在 15 名接受脑肿瘤切除清醒手术的患者中，分别以不同的 IED 和 IS 值诱发 BEPs：5 mm-5 mA、5 mm-10 mA 和 10 mm-10 mA。结果无论是皮层刺激还是轴突刺激，N1 波的振幅都随着双极刺激强度的增加而增加，而 N1 波峰值延迟不受刺激参数的影响。结论了解刺激参数与 BEP 之间的关系对于确定所产生的 N1 波是否准确反映了潜在的结构解剖学至关重要。本研究通过考察 IED 和 IS 对 N1 波的影响，迈出了描述常见双极刺激参数对 BEP 稳健性影响的第一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.