Renal involvement in adults with cystic fibrosis: Study of 89 patients

Abstract

Introduction

We are assisting to an increase in survival rates among individuals with cystic fibrosis (CF). Until now, renal involvement was a minority issue, but with the rise in life expectancy, we will likely see an increase in its prevalence. Our main objective was to assess renal function in CF and study risk factors associated with its deterioration.

Methods

A cross-sectional, retrospective study was conducted, including adults with CF. Clinical, respiratory function, microbiological, blood and urine analysis, and major chronic treatments received were collected.

Results

Eighty nine patients with a mean age of 35 ± 12 years were analyzed. Mean serum creatinine levels were 0.8 ± 0.2 mg/dL. 10.6% had a glomerular filtration rate less than 90 ml/min/1.73 m². No patient showed albuminuria. In multivariate model, only age was an independent risk factor for reduced glomerular filtration (OR 0.344, 95% CI 0.004−0.017, p = 0.002).

Conclusions

11% of CF adults show decreased glomerular filtration, with age being the sole independent risk factor. Vigilance for this uncommon condition is crucial.