In silico evaluation of corneal patch eluting anti-VEGF agents concept

IF 4.4 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Marcin K. Heljak , Sumeyye Cesur , Elif Ilhan , Wojciech Swieszkowski , Oguzhan Gunduz , Ewa Kijeńska-Gawrońska
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引用次数: 0

Abstract

This study introduces a novel approach utilizing a temporary drug-eluting hydrogel corneal patch to prevent neovascularization, alongside a numerical predictive tool for assessing the release and transport kinetics of bevacizumab (BVZ) after the keratoplasty. A key focus was investigating the impact of tear film clearance on the release kinetics and drug transport from the designed corneal patch. The proposed tear drug clearance model incorporates the physiological mechanism of lacrimal flow (tear turnover), distinguishing itself from previous models. Validation against experimental data confirms the model’s robustness, despite limitations such as a 2D axisymmetrical framework and omission of blink frequency and saccadic eye movements potential effects. Analysis highlights the significant influence of lacrimal flow on ocular drug transport, with the corneal patch extending BVZ residence time compared to topical administration. This research sets the stage for exploring multi-layer drug-eluting corneal patches as a promising therapeutic strategy in ocular health.

Abstract Image

角膜贴片洗脱抗血管内皮生长因子药物概念的硅学评估
本研究介绍了一种利用临时药物洗脱水凝胶角膜贴片防止新生血管形成的新方法,以及一种用于评估角膜移植术后贝伐单抗(BVZ)释放和运输动力学的数字预测工具。重点是研究泪膜清除率对设计的角膜贴片释放动力学和药物运输的影响。所提出的泪液药物清除模型结合了泪液流动(泪液周转)的生理机制,有别于以往的模型。尽管存在二维轴对称框架、忽略眨眼频率和眼球运动潜在影响等限制,但根据实验数据进行的验证证实了该模型的稳健性。分析凸显了泪液流动对眼部药物运输的重要影响,与局部用药相比,角膜贴片延长了BVZ的停留时间。这项研究为探索多层药物洗脱角膜贴片作为眼部健康治疗策略奠定了基础。
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来源期刊
CiteScore
8.80
自引率
4.10%
发文量
211
审稿时长
36 days
期刊介绍: The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.
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