The relationship between mindfulness and empathy with the oxytocinergic system in persons with schizophrenia spectrum disorders – A proof-of-concept randomized controlled trial (OXYGEN)

IF 5.3 1区 心理学 Q1 PSYCHOLOGY, CLINICAL
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Abstract

Background

The present study explored the feasibility and acceptability as well as the impact of mindfulness-based group therapy (MBGT) on oxytocin levels (OXT) and clinical parameters in outpatients with schizophrenia spectrum disorders (SSD).

Methods

In a randomized-controlled design, outpatients with SSD (N = 48) were assigned to either MBGT in addition to German university-level treatment as usual (MBGT+TAU; n = 25) or TAU (n = 23). At baseline and at four-week post-intervention, clinical parameters and OXT levels were determined.

Results

Results indicate high feasibility and acceptance with a 95.7% adherence- and 94% retention- rate of MBGT in SSD. While no significant changes in empathy were observed, MBGT+TAU demonstrated a significant reduction in positive symptoms (Positive and Negative Syndrom Scale) compared to TAU at post-intervention. OXT levels were significantly increased in MBGT+TAU at post-intervention, suggesting a potential link between mindfulness and the oxytocinergic system in SSD. Additionally, improvements in various clinical parameters were indicated.

Conclusion

The study contributes to the growing evidence supporting feasibility, acceptability, and positive effects of MBGT in outpatients with SSD, emphasizing the need for further research to solidify these findings. Overall, this work sheds first evidence on the intersection of mindfulness, oxytocin, and clinical outcomes in SSD.

精神分裂症谱系障碍患者的正念和移情与催产素能系统之间的关系--概念验证随机对照试验(OXYGEN)
背景本研究探讨了正念团体疗法(MBGT)的可行性、可接受性以及对精神分裂症谱系障碍(SSD)门诊患者催产素水平(OXT)和临床参数的影响。方法在随机对照设计中,SSD门诊患者(48人)被分配接受德国大学水平的常规治疗(MBGT+TAU;25人)之外的MBGT或TAU(23人)治疗。结果表明,MBGT 在 SSD 中的可行性和接受度都很高,坚持率为 95.7%,保留率为 94%。虽然在移情方面没有观察到明显变化,但在干预后,MBGT+TAU 与 TAU 相比,阳性症状(阳性和阴性综合征量表)明显减少。在干预后,MBGT+TAU 的催产素水平明显提高,这表明正念与 SSD 的催产素能系统之间存在潜在联系。结论这项研究为越来越多的证据证明正念疗法在门诊 SSD 患者中的可行性、可接受性和积极效果做出了贡献,同时强调了进一步研究以巩固这些发现的必要性。总之,这项研究首次证明了正念、催产素与 SSD 临床疗效之间的交叉关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.70
自引率
5.70%
发文量
38
审稿时长
33 days
期刊介绍: The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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